Abstract
VC-IP-loaded PLGA NS emulsions can effectively inhibit DNA damage in skin biopsies due to the anti-oxidizing effect of the reduced vitamin C, which is efficiently delivered deep into the skin due to the enhanced skin permeability created by the PLGA NSs, as discussed in Sect. 6.5. Based on these findings, whitening and anti-aging cosmetics containing PLGA NSs—named “NanoCrysphere®”—were launched in 2004 by Hosokawa Co. Ltd. Medical skincare PLGA NSs have been developed by continuously supplying a sufficient amount of ceramide or its precursors acting on the ceramide production pathway, as well as cell-activating or anti-inflammatory agents to sensitive or atopic dermatitis skin. Powder- and liquid-type foundations containing PLGA NSs encapsulated with ceramide, which increase the skin’s moisture content and inhibit TEWL, were developed. A compacted powder product was created which showed efficient anti-p-acnes-agent delivery to the pores by PLGA NSs. Hinokitiol, a hair-growth ingredient, can be much easily delivered to the hair follicle using a PLGA NS suspension than by the conventional technology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Tsujimoto, H., Hara, K., Huang, C.C., Yokoyama, T., Yamamoto, H., Takeuchi, H., Kawashima, Y., Akagi, K., Miwa, N.: Percutaneous absorption study of biodegradable PLGA nano-spheres via human skin biopsies. J. Soc. Powder Technol., Japan. 41, 867–875 (2004)
Tsujimoto, H.: Development of functional skin and scalp care cosmetics using biodegradable PLGA nanospheres. Drug Deliv. Syst. 21(4), 405–416 (2006)
Elias, P.M.: Bpidermal lipids. barrier function, and desquamalion. J. Invest. Dermatol. 80, 44–49 (1983)
Tsukada, Y., Sasai, A., Tsujimoto, H., Yamamoto, H., Kawashima, Y., Miwa, N.: Practical use of PLGA nanospheres used as DDS carriers for cosmetics. Cosmet. Stage. 7(4), 42–51 (2013)
Sasai, A., Matsuzaki, K., Tsujimoto, H., Yamamoto, H., Kawashima, Y., Miwa, N.: PLGA nano-sphere used as DDS carriers for hair restorer. Fragr. J. 41(11), 49–55 (2013)
Tsujimoto, H., Hara, K., Tsukada, Y., Huang, C.C., Kawashima, Y., Arakaki, M., Okayasu, H., Mimura, H., Miwa, N.: Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects. Bioorg. Med. Chem. Lett. 17, 4771–4777 (2007)
Tsujimoto, H., Hara, K., Bando, Y., Tsukada, Y.: Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects. Fragr. J. 12, 55–62 (2007)
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Kawashima, Y. (2019). Application of PLGA NSs to Cosmetics. In: Spherical Crystallization as a New Platform for Particle Design Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-13-6786-1_7
Download citation
DOI: https://doi.org/10.1007/978-981-13-6786-1_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-6785-4
Online ISBN: 978-981-13-6786-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)