Abstract
Viruses attack host cells using its machinery to infuse their genome and replicate themselves. Genome is the source of variation. Harmful, neutral, and beneficial sequences transfer between species and make the world more diverse. Viruses show amazing shapes, biophysical characteristics, and biochemical mechanisms. Studies of virus internalization and targeting strategies give prototypes for delivery vehicles in drug design. Our goals are to apply all knowledge for the benefit of people and find the means to avoid dangers.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Balasubramanian A, Manzano M, Teramoto T, Pilankatta R, Padmanabhan R (2016) High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Res 134:6–16. https://doi.org/10.1016/j.antiviral.2016.08.014. Epub 2016 Aug 15. PubMed PMID: 27539384; PubMed Central PMCID: PMC5065773
Born D, Reuter L, Mersdorf U, Mueller M, Fischer MG, Meinhart A, Reinstein J (2018) Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus. Proc Natl Acad Sci USA 115(28):7332–7337. https://doi.org/10.1073/pnas.1805376115. Epub 2018 Jun 25. PubMed PMID: 29941605; PubMed Central PMCID: PMC6048507
Chavez-Calvillo G, Martin S, Hamm C, Sztuba-Solinska J (2018) The structure-to-function relationships of Gammaherpesvirus-encoded long non-coding RNAs and their contributions to viral pathogenesis. Noncoding RNA 4(4). pii: E24. doi: 10.3390/ncrna4040024. Review. PubMed PMID: 30261651
Chun J, Yang HE, Kim DH (2018) Identification and molecular characterization of a novel partitivirus from trichoderma atroviride NFCF394. Viruses 10(11). pii: E578.: 10.3390/v10110578. PubMed PMID: 30360465
Cook JD, Soto-Montoya H, Korpela MK, Lee JE (2015) Electrostatic architecture of the Infectious Salmon Anemia Virus (ISAV) Core fusion protein illustrates a Carboxyl-Carboxylate pH Sensor. J Biol Chem 290(30):18495–18504. https://doi.org/10.1074/jbc.M115.644781. Epub 2015 Jun 16. PubMed PMID: 26082488; PubMed Central PMCID: PMC4513110
Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E (2002) Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1. Structure 10(7):999–1011. PubMed PMID: 12121655
Dong Y, Liu Y, Jiang W, Smith TJ, Xu Z, Rossmann MG (2017) Antibody-induced uncoating of human rhinovirus B14. Proc Natl Acad Sci USA 114(30):8017–8022. https://doi.org/10.1073/pnas.1707369114. Epub 2017 Jul 10. PubMed PMID: 28696310; PubMed Central PMCID: PMC5544331
Fu Q, Shaik MM, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC, Seaman MS, Chen B, Chou JJ (2018) Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci USA 115(38):E8892–E8899. https://doi.org/10.1073/pnas.1807259115. Epub 2018 Sep 5. PubMed PMID: 30185554; PubMed Central PMCID: PMC6156635
Ho KL, Gabrielsen M, Beh PL, Kueh CL, Thong QX, Streetley J, Tan WS, Bhella D (2018) Structure of the Macrobrachium rosenbergii nodavirus: A new genus within the Nodaviridae?, e3000038. PLoS Biol 16(10). https://doi.org/10.1371/journal.pbio.3000038. [Epub ahead of print] PubMed PMID: 30346944
Koonin EV, Dolja VV (2018) Metaviromics: a tectonic shift in understanding virus evolution. Virus Res. 246:A1–A3. https://doi.org/10.1016/j.virusres.2018.02.001
Krupovic M, Koonin EV(2014Jun 18) Evolution of eukaryotic single-stranded DNA viruses of the Bidnaviridae family from genes of four other groups of widely different viruses. Sci Rep.;4:5347. https://doi.org/10.1038/srep05347. PubMed PMID: 24939392; PubMed Central PMCID: PMC4061559
Kurochkina N, Choekyi T (2011) Helix-helix interfaces and ligand binding. J Theor Biol 283:92–102
Liu J, Deng Y, Dey AK, Moore JP, Lu M (2009) Structure of the HIV-1 gp41membrane-proximal ectodomain region in a putative prefusion conformation. Biochemistry 48(13):2915–2923. https://doi.org/10.1021/bi802303b. PubMed PMID: 19226163; PubMed Central PMCID: PMC2765501
Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA (2016) The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science 354(6318):1434–1437. PubMed PMID: 27980210
Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH (2018) Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proc Natl Acad Sci USA 115(39):E9201–E9210. https://doi.org/10.1073/pnas.1805797115. Epub 2018 Sep 7. PubMed PMID: 30194229; PubMed Central PMCID: PMC6166816
Nozawa K, Schneider TR, Cramer P (2017) Core mediator structure at 3.4 Å extends model of transcription initiation complex. Nature. https://doi.org/10.1038/nature22328. [Epub ahead of print]
Pflug A, Lukarska M, Resa-Infante P, Reich S, Cusack S (2017) Structural insights into RNA synthesis by the influenza virus transcription-replication machine. Virus Res 20. pii: S0168–1702(16)30782–1. https://doi.org/10.1016/j.virusres.2017.01.013. [Epub ahead of print]
Singh AK, Nguyen TH, Vidovszky MZ, Harrach B, Benko M, Kirwan A, Joshi L, Kilcoyne M, Berbis MÁ, Cañada FJ, Jiménez-Barbero J, Menéndez M, Wilson SS, Bromme BA, Smith JG, van Raaij MJ (2018) Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre. J Gen Virol 99(11):1494–1508. https://doi.org/10.1099/jgv.0.001145. Epub 2018 Oct 2. PubMed PMID: 30277856
Teramoto T, Balasubramanian A, Choi KH, Padmanabhan R (2017) Serotype-specific interactions among functional domains of dengue virus 2 nonstructural proteins (NS) 5 and NS3 are crucial for viral RNA replication. J Biol Chem 292(23):9465–9479. https://doi.org/10.1074/jbc.M117.775643. Epub 2017 Apr 10. PubMed PMID: 28396347; PubMed Central PMCID: PMC5465476
Teramoto T, Boonyasuppayakorn S, Handley M, Choi KH, Padmanabhan R (2014) Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness. J Biol Chem 289(32):22385–22400. https://doi.org/10.1074/jbc.M114.584466. Epub 2014 Jun 5. PubMed PMID: 24904061; PubMed Central PMCID: PMC4139246
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Kurochkina, N. (2019). Viruses. In: Protein Structure and Modeling. Springer, Singapore. https://doi.org/10.1007/978-981-13-6601-7_7
Download citation
DOI: https://doi.org/10.1007/978-981-13-6601-7_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-6600-0
Online ISBN: 978-981-13-6601-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)