Abstract
MEMS-based microcantilevers have become an indispensable technique for mass sensing in the last decade. Presently, the need has come to scale down to nanoscale cantilevers for better and faster sensing. Previously, metallic cantilevers were mostly used for biochemical/analyte detection which is more expensive compared to the polymeric ones. Arrays of sensors can be fabricated easily as SU-8 is highly resistant to chemicals. In addition, SU-8 is also biocompatible, making it the most suitable material for biochemical sensors. Furthermore, due to its low Young’s modulus, high sensitivity can be achieved. Polymeric nanocantilevers have been used in this study for detection of BSA (Bovine Serum Albumin) in a short time and low amount of concentration. Deflection was measured and observed through optical beam deflection technique and optical diffraction-based approach using high-speed camera.
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References
Wu G, Datar RH, Hansen KM, Thundat T, Cote RJ, Majumdar A (2001) Bioassay of prostate-specific antigen (PSA) using microcantilevers. Nat Biotechnol 19:856–860
Lang H, Hegner M, Gerber C (2005) Cantilever array sensors. Mater Today 8:30–36
Nakagawa K, Hashiguchi G, Kawakatsu, H (2009) Small single-crystal silicon cantilevers formed by crystal facets for atomic force microscopy. Rev Sci Instrum 80(9):095104. 8 Sep 2009
Nam HJ, Kim YS, Lee CS, Jin WH, Jang SS, Cho IJ, Bu JU, Choi WB, Choi SW (2007) Silicon nitride cantilever array integrated with silicon heaters and piezoelectric detectors for probe-based data storage. Sens Actuators A Phys 134:329–333
Basu AK, Sarkar H, Bhattacharya S (2016) Fabrication and resilience measurement of thin aluminium cantilevers using scanning probe microscopy. In: Foundations and frontiers in computer, communication and electrical engineering—Proceedings of the 3rd international conference on foundations and frontiers in computer, communication and electrical engineering, C2E2-2016
Reddy CVB, Khaderbad MA, Gandhi S, Kandpal M, Patil S, Chetty KN, Rajulu KG, Chary PCK, Ravikanth M, Rao VR (2012) Piezoresistive SU-8 cantilever with Fe(III)porphyrin coating for CO sensing. IEEE Trans Nanotechnol 11:701–706. https://doi.org/10.1109/TNANO.2012.2190619
Pandya HJ, Kim HT, Roy R, Desai JP (2014) MEMS based low cost piezoresistive microcantilever force sensor and sensor module. Mater Sci Semicond Process 19:163–173. https://doi.org/10.1016/j.mssp.2013.12.016
Basu AK, Sah AN, Pradhan A, Bhattacharya S (2019) Poly-L-Lysine functionalised MWCNT-rGO nanosheets based 3-d hybrid structure for femtomolar level cholesterol detection using cantilever based sensing platform. Sci Rep 9(1):3686. 6 Mar 2019
Basu AK, Tatiya S, Bhatt G, Bhattacharya S (2019) Fabrication Processes for Sensors for Automotive Applications: a Review. In: Sensors for automotive and aerospace applications 2019, Springer, Singapore, pp 123–142
Hermans RI, Dueck B, Ndieyira JW, McKendry RA, Aeppli G (2016) Optical diffraction for measurements of nano-mechanical bending. Sci Rep 6:26690. 3 Jun 2016
Acknowledgements
I sincerely like to acknowledge Dr. Shraddha Singh, BSBE, IITK, Sayma Ayaz, Nanoscience, IITK, Dr. Prabhat Dwivedi, Nanoscience, Dr. Seema Sharma, Nanoscience, IITK for fabrication and SEM Facilities. I will also like to acknowledge Dr. Rodolfo I. Hermans and Dr. Benjamin Dueck from the London Centre for Nanotechnology, UCL for all communications.
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Basu, A.K., Sah, A.N., Pradhan, A., Bhattacharya, S. (2019). BSA Detection on Polymeric Nanocantilever. In: Kumar, M., Pandey, R., Kumar, V. (eds) Advances in Interdisciplinary Engineering . Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-13-6577-5_56
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DOI: https://doi.org/10.1007/978-981-13-6577-5_56
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