Edible Mushrooms as Neuro-nutraceuticals: Basis of Therapeutics

Remya, V. R.; Chandra, Goutam; Mohanakumar, K. P.

doi:10.1007/978-981-13-6382-5_2

Edible Mushrooms as Neuro-nutraceuticals: Basis of Therapeutics

V. R. Remya³,
Goutam Chandra³ &
K. P. Mohanakumar³

Chapter
First Online: 14 May 2019

1296 Accesses
1 Citations

Abstract

Mushrooms, the macro-fungi with distinctive fruiting bodies and mycelia, are valued throughout the world not only for their nutritive values but also for their medicinal uses. The former desirable property of mushrooms derives out of their rich contents of vitamins, trace elements, and minerals and appetite-enhancing flavors, but the therapeutic values result from its antioxidant and immunomodulatory activities, from its ability to activate very specific neuronal receptors, and from its capacity to rejuvenate cellular metabolism. Reactive oxygen species cause extensive damage to cells and tissues by interfering with normal metabolism, which are aggravated during stressful environments, such as during infections, stress, metabolic diseases, and various degenerative disorders including neurodegenerative diseases, cardiovascular diseases, and accelerated or normal aging. Mushrooms contain many biologically dynamic compounds, some of which are neuroactive substances, free radical scavengers, anti-apoptotic factors, and nerve growth factor stimulators that exert positive effects on brain cells, all of which essentially qualify them as good neuro-nutraceuticals that help in the protection of different neural cells, in vivo and in vitro. While discussing the neuroprotective and neuromodulatory properties of mushrooms, we rationally postulate here indirect benefits of these fungi through the enhanced environment for gut microbiome that are meaningful for healthy brain functions.

This is a preview of subscription content, log in via an institution.

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 169.00; Price excludes VAT (USA)

Softcover Book: USD 219.99; Price excludes VAT (USA)

Hardcover Book: USD 219.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

ROS:: Reactive oxygen species
LPS:: Lipopolysaccharides
RNS:: Reactive nitrogen species
ER:: Endoplasmic reticulum
TNF:: Tumor necrosis factor
CNS:: Central nervous system
NGF:: Nerve growth factor
BBB:: Blood-brain barrier
AD:: Alzheimer’s disease
ICV:: Intracerebroventricular
STZ:: Streptozotocin
PKC:: Protein kinase C
PD:: Parkinson’s disease
MPP⁺ :: 1-Methyl-4-phenylpyridinium
MPTP:: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
GDNF:: Glial cell-derived neurotrophic factor
BDNF:: Brain-derived neurotrophic factor
OCTN1:: Organic cation transporter
SLC22A4:: Solute carrier family 22, member 4
IL-1β:: Interleukin 1β
JNK:: c-Jun N-terminal kinases
p38 MAPK:: p38 mitogen-activated protein kinases
IRE1α:: Inositol-requiring protein 1alpha
TRAF2:: TNF receptor-associated factor 2
C/EBP:: CCAAT-enhancer-binding proteins
CHOP :: C/EBP homologous protein
NF-κB:: Nuclear factor-κB
Bax:: Bcl-2-associated protein x
Bcl-2:: B-cell lymphoma 2
PKB/Akt:: Protein kinase B
mTOR:: The mammalian target of rapamycin
Bid:: BH3 interacting-domain death agonist

References

Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF (2012) Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evid Based Complement Alternat Med 2012:1–12. https://doi.org/10.1155/2012/464238
Article Google Scholar
Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 138(2):155–175. https://doi.org/10.1016/j.pharmthera.2013.01.004
Article CAS PubMed Google Scholar
Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci 90(17):7915–7922
Article CAS Google Scholar
Aruoma OI, Spencer JP, Mahmood N (1999) Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food Chem Toxicol 37(11):1043–1053. https://doi.org/10.1016/S0278-6915(99)00098-8
Article CAS PubMed Google Scholar
Attarat J, Phermthai T (2014) Bioactive compounds in three edible Lentinus mushrooms. Walailak J Sci Technol 12:491–504. https://doi.org/10.2004/wjst.v12i2.842
Article Google Scholar
Aygul N, Duzenli MA, Ozdemir K, Altunkeser BB (2010) A case report of an unusual complication of Amanita phalloides poisoning: development of cardiogenic shock and its successful treatment with intra-aortic balloon counterpulsation. Toxicon 55:630–632. https://doi.org/10.1016/j.toxicon.2009.10.022
Article CAS PubMed Google Scholar
Baskaran A, Chua KH, Sabaratnam V, Ravishankar Ram M, Kuppusamy UR (2017) Pleurotus giganteus (Berk. Karun & Hyde), the giant oyster mushroom inhibits NO production in LPS/H₂O₂ stimulated RAW 264.7 cells via STAT 3 and COX-2 pathways. BMC Complement Altern Med 17(1):40. https://doi.org/10.1186/s12906-016-1546-6
Article CAS PubMed PubMed Central Google Scholar
Bedry R, Baudrimont I, Deffieux G, Creppy EE, Pomies JP, Ragnaud JM, Dupon M, Neau D, Gabinski C, De Witte S, Chapalain JC, Beylot J, Godeau P (2001) Wild-mushroom intoxication as a cause of Rhabdomyolysis. N Engl J Med 345:798–802. https://doi.org/10.1056/NEJMoa010581
Article CAS Google Scholar
Brondz I, Ekeberg D, Høiland K, Bell DS, Annino AR (2007) The real nature of the indole alkaloids in Cortinarius infractus: evaluation of artifact formation through solvent extraction method development. J Chromatogr A 1148:1–7. https://doi.org/10.1016/j.chroma.2007.02.074
Article CAS PubMed Google Scholar
Chakrabarti S, Mohanakumar KP (2016) Aging and neurodegeneration: a tangle of models and mechanisms. Aging Dis 7(2):111–113. https://doi.org/10.14336/AD.2016.0312
Article PubMed PubMed Central Google Scholar
Chandra G, Shenoi RA, Anand R, Rajamma U, Mohanakumar KP (2017) Reinforcing mitochondrial functions in aging brain: an insight into Parkinson’s disease therapeutics. J Chem Neuroanat S0891-0618(17):30122–30129. https://doi.org/10.1016/j.jchemneu.2017.12.004
Article CAS Google Scholar
Chen CC, Shiao YJ, Lin RD, Shao YY, Lai MN, Lin CC, Ng LT, Kuo YH (2006) Neuroprotective diterpenes from the fruiting body of Antrodia camphorata. J Nat Prod 69:689–691. https://doi.org/10.1021/np0581263
Article CAS PubMed Google Scholar
Chen LW, Wang YQ, Wei LC, Shi M, Chan YS (2007) Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson’s disease. CNS Neurol Disord Drug Targets 6(4):273–281
Article CAS Google Scholar
Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L (2015) Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms. Int J Med Mushrooms 17(3):287–295
Article Google Scholar
Cheung WWM, Hui WS, Chu PWK, Chiu SW, Ip NY (2000) Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett 486(3):291–296
Article CAS Google Scholar
Choi J, Horikawa M, Okumura H, Kodani S, Nagai K, Hashizume D, Koshino H, Kawagishi H (2009) Endoplasmic reticulum (ER) stress protecting compounds from the mushroom Mycoleptodonoides aitchisonii. Tetrahedron 65:221–224. https://doi.org/10.1016/J.TET.2008.10.068
Article CAS Google Scholar
Choi JH, Suzuki T, Okumura H, Noguchi K, Kondo M, Nagai K, Hirai H, Kawagishi H (2014) Endoplasmic reticulum stress suppressive compounds from the edible mushroom Mycoleptodonoides aitchisonii. J Nat Prod 77:1729–1733. https://doi.org/10.1021/np500075m
Article CAS PubMed Google Scholar
Choi YJ, Yang HS, Jo JH, Lee SC, Park TY, Choi BS, Seo KS, Huh CK (2015) Anti-amnesic effect of fermented Ganoderma lucidum water extracts by lactic acid bacteria on scopolamine-induced memory impairment in rats. Prev Nutr Food Sci 20(2):126–132. https://doi.org/10.3746/pnf.2015.20.2.126
Article CAS PubMed PubMed Central Google Scholar
Chowdhury M, Kubra K, Ahmed S (2015) Screening of antimicrobial, antioxidant properties and bioactive compounds of some edible mushrooms cultivated in Bangladesh. Ann Clin Microbiol Antimicrob 14:8. https://doi.org/10.1186/s12941-015-0067-3
Article CAS PubMed PubMed Central Google Scholar
Clarke D, Crews C (2013) Natural toxicants: mushrooms and toadstools. Encycl Food Saf 2:269–276. https://doi.org/10.1016/B978-0-12-378612-8.00429-7
Article Google Scholar
Curtis DR, Lodge D, McLennan H (1979) The excitation and depression of spinal neurones by ibotenic acid. J Physiol 291:19–28
Article CAS Google Scholar
Das SK, Masuda M, Sakurai A, Sakakibara M (2010) Medicinal uses of the mushroom Cordyceps militaris: current state and prospects. Fitoterapia 81(8):961–968. https://doi.org/10.1016/j.fitote.2010.07.010
Article PubMed Google Scholar
Dong Y, Jing T, Meng Q, Liu C, Hu S, Ma Y, Liu Y, Lu J, Cheng Y, Wang D, Teng L (2014) Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats. Biomed Res Int 2014:1–11. https://doi.org/10.1155/2014/160980
Article Google Scholar
Ennecker-Jans SAM, van Daele PLA, Blonk MI, Varin DSE, van Laar JAM (2007) Amatoxin poisoning due to soup from personally picked deathcap mushrooms (Amanita phalloides). Ned Tijdschr Geneeskd 151:764–768
CAS PubMed Google Scholar
Fawcett TW, Martindal JL, Guyton KZ, Hai T, Holbrook NJ (1999) Complexes containing activating transcription factor (ATF)/cAMP-responsive element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response. Biochem J 339(Pt 1):135–141
CAS PubMed PubMed Central Google Scholar
Frangež R, Šuput D, Molgó J, Benoit E (2017) Ostreolysin A/pleurotolysin and equinatoxins: structure, function and pathophysiological effects of these pore-forming proteins. Toxins (Basel) 9:1–10. https://doi.org/10.3390/toxins9040128
Article CAS Google Scholar
French AL, Garrettson LK (1988) Poisoning with the North American Jack O’Lantern mushroom, Omphalotus illudens. J Toxicol Clin Toxicol 26:81–88
Article CAS Google Scholar
Friedman M (2016) Mushroom polysaccharides: chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods 5(4):pii: E80. https://doi.org/10.3390/foods5040080
Article CAS Google Scholar
Ganeshpurkar A, Pardhi P, Bhadoriya SS, Jain N, Rai G, Jain AP (2015) Antioxidant potential of white oyster culinary-medicinal mushroom, Pleurotus Florida (higher basidiomycetes). Int J Med Mushrooms 17:491–498
Article Google Scholar
Geissler T, Brandt W, Porzel A, Schlenzig D, Kehlen A, Wessjohann L, Arnold N (2010) Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorg Med Chem 18:2173–2177. https://doi.org/10.1016/j.bmc.2010.01.074
Article CAS PubMed Google Scholar
Geng Y, Zhu S, Cheng P, Lu ZM, Xu HY, Shi JS, Xu ZH (2017) Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharides (LPS)-stimulated BV-2 microglia. Phytomedicine 26:55–61. https://doi.org/10.1016/j.phymed.2017.01.005
Article CAS Google Scholar
Gokce EC, Kahveci R, Gürer B, Aksoy N, Gokce A, Sargon MF, Cemil B, Erdogan B, Kahveci O (2015) Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats. Injury 46(11):2146–2155. https://doi.org/10.1016/j.injury.2015.08.017
Article PubMed Google Scholar
Graeme KA (2014) Mycetism: a review of the recent literature. J Med Toxicol 10:173–189. https://doi.org/10.1007/s13181-013-0355-2
Article CAS PubMed PubMed Central Google Scholar
Gründemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A, Schömig E (2005) Discovery of the ergothioneine transporter. Proc Natl Acad Sci USA 102(14):5256–5261
Article Google Scholar
Guo SS, Cui XL, Rausch WD (2016) Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. Am J Neurodegener Dis 5(2):131–144
PubMed PubMed Central Google Scholar
Han ZH, Ye JM, Wang GF (2013) Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol 52:66–71. https://doi.org/10.1016/j.ijbiomac.2012.09.009
Article CAS PubMed Google Scholar
Holliday JC, Cleaver P, Loomis-Powers M, Patel D (2004) Analysis of quality and techniques for hybridization of medicinal fungus Cordyceps sinensis (Berk.)Sacc. (Ascomycetes). Int J Med Mushrooms 6:151–164. https://doi.org/10.1615/IntJMedMushr.v6.i2.60
Article CAS Google Scholar
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G (2017) Polysaccharides from Ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer’s disease. Stem Cell Rep 8:84–94. https://doi.org/10.1016/j.stemcr.2016.12.007
Article CAS Google Scholar
Hunt WT, Kamboj A, Anderson HD, Anderson CM (2010) Protection of cortical neurons from excitotoxicity by conjugated linoleic acid. J Neurochem 115(1):123–130. https://doi.org/10.1111/j.1471-4159.2010.06908.x
Article CAS PubMed Google Scholar
Ishimoto T, Nakamichi N, Hosotani H, Masuo Y, Sugiura T, Kato Y (2014) Organic cation transporter mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons. PLoS One 9(2):e89434. https://doi.org/10.1371/journal.pone.0089434
Article CAS PubMed PubMed Central Google Scholar
Israelyan N, Margolis KG (2018) Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacol Res 132:1–6. https://doi.org/10.1016/j.phrs.2018.03.020
Article CAS PubMed PubMed Central Google Scholar
Jaiswal P, Mohanakumar KP, Rajamma U (2015) Serotonin mediated immunoregulation and neural functions: complicity in the aetiology of autism spectrum disorders. Neurosci Biobehav Rev 55:413–431. https://doi.org/10.1016/j.neubiorev.2015.05.013
Article CAS PubMed Google Scholar
Jang MJ, Lee YH, Ju YC, Kim SM, Koo HM (2013) Effect of color of light emitting diode on development of fruit body in Hypsizygus marmoreus. Mycobiology 41:63–66. https://doi.org/10.5941/MYCO.2013.41.1.63
Article PubMed PubMed Central Google Scholar
Jo WS, Hossain MA, Park SC (2014) Toxicological profiles of poisonous, edible, and medicinal mushrooms. Mycobiology 42:215–220. https://doi.org/10.5941/MYCO.2014.42.3.215
Article PubMed PubMed Central Google Scholar
Karami A, Eyjolfsdottir H, Vijayaraghavan S, Lind G, Almqvist P, Kadir A, Linderoth B, Andreasen N, Blennow K, Wall A, Westman E, Ferreira D, Kristoffersen Wiberg M, Wahlund LO, Seiger Å, Nordberg A, Wahlberg L, Darreh-Shori T, Eriksdotter M (2015) Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer’s disease. Alzh Dement 11(11):1316–1328. https://doi.org/10.1016/j.jalz.2014.11.008
Article Google Scholar
Kawagishi H, Ando M, Sakamoto H, Yoshida S, Ojima F, Ukai N, Furukawa S (1991) Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum. Tetrahedron Lett 32(35):4561–4564. https://doi.org/10.1016/0040-4039(91)80039-9
Article CAS Google Scholar
Kawagishi H, Ishiyama D, Mori H, Sakamoto H, Ishiguro Y, Furukawa S, Li J (1997) Dictyophorines A and B, two stimulators of NGF-synthesis from the mushroom Dictyophora indusiata. Phytochemistry 45(6):1203–1205. https://doi.org/10.1016/S0031-9422(97)00144-1
Article CAS PubMed Google Scholar
Kim SP, Lee SJ, Nam SH, Friedman M (2017) Turmeric bioprocessed with mycelia from the shiitake culinary-medicinal mushroom Lentinus edodes (Agaricomycetes) protects mice against salmonellosis. Int J Med Mushrooms 19(4):363–376. https://doi.org/10.1615/IntJMedMushrooms.v19.i4.70
Article PubMed Google Scholar
Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG (2003) The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh 49(1):38–45
CAS PubMed Google Scholar
Kuo H-C, Lu C-C, Shen C-H, Tung S-Y, Hsieh MC, Lee K-C, Lee L-Y, Chen C-C, Teng C-C, Huang W-S, Chen T-C, Lee K-F (2016) Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med 14:78. https://doi.org/10.1186/s12967-016-0831-y
Article CAS PubMed PubMed Central Google Scholar
Lamhonwah AM, Hawkins CE, Tam C, Wong J, Mai L, Tein I (2008) Expression patterns of the organic cation/carnitine transporter family in adult murine brain. Brain Dev 30(1):31–42
Article Google Scholar
Lee IK, Yun BS, Kim YH, Yoo ID (2002a) Two neuroprotective compounds from mushroom Daldinia concentrica. J Microbiol Biotechnol 12:692–694
CAS Google Scholar
Lee I-K, Yun BS, Han G, Cho DH, Kim YH, Yoo ID (2002b) Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata. J Nat Prod 65:1769–1772. https://doi.org/10.1021/np020163w
Article CAS PubMed Google Scholar
Lee IS, Ahn BR, Choi JS, Hattori M, Min BS, Bae KH (2011) Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett 21(21):6603–6607. https://doi.org/10.1016/j.bmcl.2011.04.042
Article CAS PubMed Google Scholar
Lee SC, Im NK, Jeong HY, Choi EH, Jeon SM, Jeong GS (2014) Neuroprotective effects of ethanol extract of Ganoderma lucidum L. on murine hippocampal cells. Kor J Pharmacogn 45(2):161–167
Google Scholar
Li L, Ng TB, Song M, Yuan F, Liu ZK, Wang CL, Jiang Y, Fu M, Liu F (2007) A polysaccharide–peptide complex from abalone mushroom (Pleurotus abalonus) fruiting bodies increases activities and gene expression of antioxidant enzymes and reduces lipid peroxidation in senescence-accelerated mice. Appl Microbiol Biotechnol 75:863–869. https://doi.org/10.1007/s00253-007-0865-4
Article CAS PubMed Google Scholar
Li IC, Chen YL, Chen WP, Lee LY, Tsai YT, Chen CC, Chen CS (2014) A genotoxicity profile of erinacine A enriched Hericium erinaceus mycelium. Toxicol Rep 1:1195–1201. https://doi.org/10.1016/j.toxrep.2014.11.009
Article CAS PubMed PubMed Central Google Scholar
Li Z, Chen X, Lu W, Zhang S, Guan X, Li Z, Wang D (2017) Anti-oxidative stress activity is essential for Amanita caesarea mediated neuroprotection on glutamate-induced apoptotic HT22 cells and an Alzheimer’s disease mouse model. Int J Mol Sci 18:1623. https://doi.org/10.3390/ijms18081623
Article CAS PubMed Central Google Scholar
Lung MY, Chang YC (2011) Antioxidant properties of the edible basidiomycete Armillaria mellea in submerged cultures. Int J Mol Sci 12:6367–6384. https://doi.org/10.3390/ijms12106367
Article CAS PubMed PubMed Central Google Scholar
Madathil SK, Karuppagounder SS, Mohanakumar KP (2013) Sodium salicylate protects against rotenone-induced parkinsonism in rats. Synapse 67(8):502–514. https://doi.org/10.1002/syn.21658
Article CAS PubMed Google Scholar
Marciniak B, Ferenc T, Kusowska J, Ciećwierz J, Kowalczyk E (2010) Poisoning with selected mushrooms with neurotropic and hallucinogenic effect. Med Pr 61:583–595
CAS PubMed Google Scholar
Meuninck J (2015) Basic illustrated edible medicinal mushrooms, 1st edn. Falcon Guides, Morris Books Publishing LLC, Globe Pequot Press, Gilford, pp 85
Google Scholar
Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N (2008) Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull 31(9):1727–1732
Article CAS Google Scholar
Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T (2009) Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res 23(3):367–372. https://doi.org/10.1002/ptr.2634
Article CAS PubMed Google Scholar
Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N (2011) Effects of Hericium erinaceus on amyloid β(25–35) peptide-induced learning and memory deficits in mice. Biomed Res 32(1):67–72
Article CAS Google Scholar
Mount P, Harris G, Sinclair R, Finlay M, Becker GJ (2002) Acute renal failure following ingestion of wild mushrooms. Intern Med J 32:187–190
Article CAS Google Scholar
Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H (2006) Dilinoleoyl- phosphatidylethanolamine from Hericium erinaceum protects against ER stress- dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem 17(8):525–530. https://doi.org/10.1016/j.jnutbio.2005.09.007
Article CAS PubMed Google Scholar
Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K (2010) Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res 31(4):231–237
Article CAS Google Scholar
Nakamichi N, Taguchi T, Hosotani H, Wakayama T, Shimizu T, Sugiura T, Iseki S, Kato Y (2012) Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: possible involvement in neuronal differentiation. Neurochem Int 61(7):1121–1132. https://doi.org/10.1016/j.neuint.2012.08.004
Article CAS PubMed Google Scholar
Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kato Y (2016) Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice. Brain Behav 6(6):e00477. https://doi.org/10.1002/brb3.477
Article PubMed PubMed Central Google Scholar
Naskar A, Manivasagam T, Chakraborty J, Singh R, Thomas B, Dhanasekaran M, Mohanakumar KP (2013) Melatonin synergizes with low doses of L-DOPA to improve dendritic spine density in the mouse striatum in experimental Parkinsonism. J Pineal Res 55(3):304–312. https://doi.org/10.1111/jpi.12076
Article CAS PubMed Google Scholar
Ng TB, Wang HX (2005) Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol 57(12):1509–1519. https://doi.org/10.1211/jpp.57.12.0001
Article CAS PubMed Google Scholar
Nieminen P, Kärjä V, Mustonen AM (2008) Indications of hepatic and cardiac toxicity caused by subchronic Tricholoma flavovirens consumption. Food Chem Toxicol 46(2):781–786
Article CAS Google Scholar
Nukata M, Hashimoto T, Yamamoto I, Iwasaki N, Tanaka M, Asakawa Y (2002) Neogrifolin derivatives possessing anti-oxidative activity from the mushroom Albatrellus ovinus. Phytochemistry 59:731–737
Article CAS Google Scholar
O’Banion D, Armstrong B, Cummings RA, Stange J (1978) Disruptive behavior: a dietary approach. J Autism Child Schizophr 8(3):325–337
Article Google Scholar
Oyadomari S, Mori M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11(4):381–389. https://doi.org/10.1038/sj.cdd.4401373
Article CAS PubMed Google Scholar
Paidi RK, Nthenge-Ngumbau DN, Singh R, Kankanala T, Mehta H, Mohanakumar KP (2015) Mitochondrial deficits accompany cognitive decline following single bilateral intracerebroventricular streptozotocin. Curr Alzheimer Res 12(8):785–795
Article CAS Google Scholar
Palacios I, Lozano M, Moro C, D’Arrigo M, Rostagno MA, Martínez JA, García-Lafuente A, Guillamón E, Villares A (2011) Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chem 128:674–678. https://doi.org/10.1016/J.FOODCHEM.2011.03.085
Article CAS Google Scholar
Park IH, Chung SK, Lee KB, Yoo YC, Kim SK, Kim GS, Song KS (2004) An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch Pharm Res 27:615–618
Article CAS Google Scholar
Peng J, Wang P, Ge H, Qu X, Jin X (2015) Effects of cordycepin on the microglia-overactivation-induced impairments of growth and development of hippocampal cultured neurons. Plos One 10(5):e0125902. https://doi.org/10.1371/journal.pone.0125902
Article CAS PubMed PubMed Central Google Scholar
Phan C-W, Wong W, David P, Naidu M, Sabaratnam V (2012) Pleurotus giganteus (Berk.) Karunarathna & K.D. Hyde: nutritional value and in vitro neurite outgrowth activity in rat pheochromocytoma cells. BMC Complement Altern Med 12:102. https://doi.org/10.1186/1472-6882-12-102
Article PubMed PubMed Central Google Scholar
Phan CW, David P, Naidu M, Wong KH, Sabaratnam V (2013) Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3. BMC Complement Altern Med 13:261. https://doi.org/10.1186/1472-6882-13-261
Article PubMed PubMed Central Google Scholar
Phan CW, David P, Naidu M, Wong KH, Sabaratnam V (2015) Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol 35(3):355–368. https://doi.org/10.3109/07388551.2014.887649
Article CAS PubMed Google Scholar
Phan CW, David P, Sabaratnam V (2017) Edible and medicinal mushrooms: emerging brain food for the mitigation of neurodegenerative diseases. J Med Food 20(1):1–10. https://doi.org/10.1089/jmf.2016.3740
Article PubMed Google Scholar
Qi J, Ojika M, Sakagami Y (2000) Termitomycesphins A–D, novel neuritogenic cerebrosides from the edible chinese mushroom Termitomyces albuminosus. Tetrahedron 56:5835–5841. https://doi.org/10.1016/S0040-4020(00)00548-2
Article CAS Google Scholar
Qu Y, Sun K, Gao L, Sakagami Y, Kawagishi H, Ojika M, Qi J (2012) Termitomycesphins G and H, additional cerebrosides from the edible Chinese mushroom Termitomyces albuminosus. Biosci Biotechnol Biochem 76:791–793. https://doi.org/10.1271/bbb.110918
Article CAS PubMed Google Scholar
Rathee S, Rathee D, Rathee D, Kumar V, Rathee P (2012) Mushrooms as therapeutic agents. Rev Bras Farmacogn 22:459–474. https://doi.org/10.1590/S0102-695X2011005000195
Article CAS Google Scholar
Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P (2013) Neuronal health - can culinary and medicinal mushrooms help? J Tradit Complement Med 3:62–68. https://doi.org/10.4103/2225-4110.106549
Article PubMed PubMed Central Google Scholar
Salit RB, Shea YR, Gea-Banacloche J, Fahle GA, Abu-Asab M, Sugui JA, Carpenter AE, Quezado MM, Bishop MR, Kwon-Chung KJ (2010) Death by edible mushroom: first report of Volvariella volvacea as an etiologic agent of invasive disease in a patient following double umbilical cord blood transplantation. J Clin Microbiol 48:4329–4332. https://doi.org/10.1128/JCM.01222-10
Article CAS PubMed PubMed Central Google Scholar
Samberkar S, Gandhi S, Naidu M, Wong KH, Raman J, Sabaratnam V (2015) Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) medicinal mushrooms stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina: an in vitro study. Int J Med Mushrooms 17(11):1047–1054
Article Google Scholar
Scarmeas N, Stern Y, Tang M-X, Mayeux R, Luchsinger JA (2006) Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol 59(6):912–921. https://doi.org/10.1002/ana.20854
Article PubMed PubMed Central Google Scholar
Schlumberger S, Kristan KČ, Ota K, Frangež R, Molgό J, Sepčić K, Benoit E, Maček P (2014) Permeability characteristics of cell-membrane pores induced by ostreolysin A/pleurotolysin B, binary pore-forming proteins from the oyster mushroom. FEBS Lett 588(1):35–40. https://doi.org/10.1016/j.febslet.2013.10.038
Article CAS PubMed Google Scholar
Sengupta T, Vinayagam J, Singh R, Jaisankar P, Mohanakumar KP (2016) Plant-derived natural products for parkinson’s disease therapy. Adv Neurobiol 12:415–496. https://doi.org/10.1007/978-3-319-28383-8_23
Article CAS PubMed Google Scholar
Singh A, Verma P, Balaji G, Samantaray S, Mohanakumar KP (2016) Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neurochem Int 99:221–232. https://doi.org/10.1016/j.neuint.2016.07.003
Article CAS PubMed Google Scholar
Singh A, Verma P, Raju A, Mohanakumar KP (2018) Nimodipine attenuates the parkinsonian neurotoxin, MPTP-induced changes in the calcium binding proteins, calpain and calbindin. J Chem Neuroanat pii: S0891-0618(17)30148-5. https://doi.org/10.1016/j.jchemneu.2018.02.001
Article CAS Google Scholar
Song J, Wang Y, Teng M, Cai G, Xu H, Guo H, Liu Y, Wang D, Teng L (2015) Studies on the antifatigue activities of Cordyceps militaris fruit body extract in mouse model. Evid Based Complement Alternat Med 2015:174616. https://doi.org/10.1155/2015/174616
Article PubMed PubMed Central Google Scholar
Stenklyft PH, Augenstein WL (1990) Chlorophyllum molybdites–severe mushroom poisoning in a child. J Toxicol Clin Toxicol 28:159–168
Article CAS Google Scholar
Tong H, Xia F, Feng K, Sun G, Gao X, Sun L, Jiang R, Tian D, Sun X (2009) Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. Bioresour Technol 100:1682–1686. https://doi.org/10.1016/j.biortech.2008.09.004
Article CAS PubMed Google Scholar
Tremlett H, Bauer KC, Appel-Cresswell S, Finlay BB, Waubant E (2017) The gut microbiome in human neurological disease: a review. Ann Neurol 81(3):369–382. https://doi.org/10.1002/ana.24901
Article PubMed Google Scholar
Varshney J, Ooi JH, Jayarao BM, Albert I, Fisher J, Smith RL, Patterson AD, Cantorna MT (2013) White button mushrooms increase microbial diversity and accelerate the resolution of Citrobacter rodentium infection in mice. J Nutr 143(4):526–532. https://doi.org/10.3945/jn.112.171355
Article CAS Google Scholar
Wang JH, Xu JL, Zhang JC, Liu Y, Sun HJ, Zha X (2015) Physicochemical properties and antioxidant activities of polysaccharide from floral mushroom cultivated in Huangshan Mountain. Carbohydr Polym 131:240–247. https://doi.org/10.1016/J.CARBPOL.2015.05.052
Article CAS PubMed Google Scholar
Westfall S, Lomis N, Kahouli I, Dia SY, Singh SP, Prakash S (2017) Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell Mol Life Sci 74(20):3769–3787. https://doi.org/10.1007/s00018-017-2550-9
Article CAS PubMed Google Scholar
Williams RJ, Mohanakumar KP, Beart PM (2015a) Neuro-nutraceuticals: the path to brain health via nourishment is not so distant. Neurochem Int 89:1–6. https://doi.org/10.1016/j.neuint.2015.08.012
Article CAS PubMed Google Scholar
Williams RJ, Mohanakumar KP, Beart PM (2015b) Nutraceuticals: molecular and functional insights into how natural products nourish the brain. Neurochem Int 89:1–280
Article CAS Google Scholar
Williams RJ, Mohanakumar KP, Beart PM (2016a) Neuro-nutraceuticals: further insights into their promise for brain health. Neurochem Int 95:1–3. https://doi.org/10.1016/j.neuint.2016.03.016
Article CAS PubMed Google Scholar
Williams RJ, Mohanakumar KP, Beart PM (2016b) Special issue: neuro-nutraceuticals: further insights into their promise for brain health. Neurochem Int 95:1–118
Article CAS Google Scholar
Wong KH, Sabaratnam V, Abdullah N, Kuppusamy UR, Naidu M (2009) Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus (Bull.:Fr.) Pers. extracts. Food Technol Biotechnol 47(1):47–55
CAS Google Scholar
Wong KH, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, Sabaratnam V (2011) Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med 2011:580752. https://doi.org/10.1093/ecam/neq062
Article PubMed PubMed Central Google Scholar
Wu JM, Doonan BB, Hsieh TC, Yang Q, Yang XT, Ling MT (2016) Recent advances and challenges in studies of control of cancer stem cells and the gut microbiome by the Trametes-derived polysaccharopeptide. Int J Med Mushrooms 18(8):651–660. https://doi.org/10.1615/IntJMedMushrooms.v18.i8.10
Article Google Scholar
Xu X, Yang J, Ning Z, Zhang X (2015) Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota. Food Funct 6(8):2653–2663. https://doi.org/10.1039/c5fo00689a
Article CAS PubMed Google Scholar
Xuan M, Okazaki M, Iwata N, Asano S, Kamiuchi S, Matsuzaki H, Sakamoto T, Miyano Y, Iizuka H, Hibino Y (2015) Chronic treatment with a water-soluble extract from the culture medium of Ganoderma lucidum mycelia prevents apoptosis and necroptosis in hypoxia/ischemia-induced injury of type 2 diabetic mouse brain. Evid Based Complement Alternat Med 2015:865986. https://doi.org/10.1155/2015/865986
Article PubMed PubMed Central Google Scholar
Yaguchi T, Fujikawa H, Nishizaki T (2010) Linoleic acid derivative DCP-LA protects neurons from oxidative Stress-Induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res 35(5):712–717. https://doi.org/10.1007/s11064-010-0124-4
Article CAS PubMed Google Scholar
Yang EJ, Song KS (2015) Polyozellin, a key constituent of the edible mushroom Polyozellus multiplex, attenuates glutamate-induced mouse hippocampal neuronal HT22 cell death. Food Funct 6(12):3678–3686
Article CAS Google Scholar
Yang NC, Lin HC, Wu JH, Ou HC, Chai YC, Tseng CY, Liao JW, Song TY (2012) Ergothioneine protects against neuronal injury induced by beta-amyloid in mice. Food Chem Toxicol 50(11):3902–3911. https://doi.org/10.1016/j.fct.2012.08.021
Article CAS Google Scholar
Yeh JY, Hsieh LH, Wu KT, Tsai CF (2011) Antioxidant properties and antioxidant compounds of various extracts from the edible Basidiomycete Grifola frondosa (Maitake). Molecules 16:3197–3211. https://doi.org/10.3390/molecules16043197
Article CAS PubMed PubMed Central Google Scholar
Yuswan MHMY, Al-Obaidi JR, Rahayu A, Sahidan S, Shazrul F, Fauzi D (2015) New bioactive molecules with potential antioxidant activity from various extracts of wild edible Gelam mushroom (Boletus spp.). Adv Biosci Biotechnol 6:320–329. https://doi.org/10.4236/abb.2015.64031
Article CAS Google Scholar
Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan P (2011) Ganoderma lucidum protects dopaminergic neuron degeneration through inhibition of microglial activation. Evid Based Complement Alternat Med 2011:156810. https://doi.org/10.1093/ecam/nep075
Article PubMed PubMed Central Google Scholar
Zhang Y, Luo J, Huang NH, Zhang XY (2012a) Influence of Ganoderma lucidum triterpenoids on learning memory function and ACh content in Alzheimer disease model rat. Chin J Exp Tradit Med Formulae 16(16):172–175
Google Scholar
Zhang Z, Lv G, Pan H, Pandey A, He W, Fan L (2012b) Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey. Int J Biol Macromol 51(5):1140–1146. https://doi.org/10.1016/j.ijbiomac.2012.09.002
Article CAS PubMed Google Scholar
Zhang W, Zhang Q, Deng W, Li Y, Xing G, Shi X, Du Y (2014) Neuroprotective effect of pretreatment with Ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus. Neural Regen Res 9(15):1446–1452. https://doi.org/10.4103/1673-5374.139461
Article PubMed PubMed Central Google Scholar
Zhang J, An S, Hu W, Teng M, Wang X, Qu Y, Liu Y, Yuan Y, Wang D (2016) The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer’s disease mouse model. Int J Mol Sci 17(11):pii E1810
Article Google Scholar
Zhou Y, Qu ZQ, Zeng YS, Lin YK, Li Y, Chung P, Wong R, Hägg U (2012) Neuroprotective effect of pre-administration with Ganoderma lucidum spore on rat hippocampus. Exp Toxicol Pathol 64(7–8):673–680. https://doi.org/10.1016/j.etp.2010.12.011
Article PubMed Google Scholar
Zhu WW, Liu Z, Xu HW, Chu WZ, Ye QY, Xie AM, Chen L, Li JR (2005) Effect of the oil from Ganoderma lucidum spores on pathological changes in the substantia nigra and behaviors of MPTP-treated mice. Di Yi Jun Yi Da Xue Xue Bao 25(6):667–671
PubMed Google Scholar

Download references

Acknowledgments

We acknowledge the financial support from Department of Health and Family Welfare and Department of Higher Education, Government of Kerala, India. Mahatma Gandhi University acts as our mentoring institution, support of which is acknowledged.

Conflict of Interests

The authors declare no conflict of interest in publishing this manuscript.

Author information

Authors and Affiliations

Inter University Centre for Biomedical Research & Super Speciality Hospital, Mahatma Gandhi University at Thalappady Campus, Kottayam, Kerala, India
V. R. Remya, Goutam Chandra & K. P. Mohanakumar

Authors

V. R. Remya
View author publications
You can also search for this author in PubMed Google Scholar
Goutam Chandra
View author publications
You can also search for this author in PubMed Google Scholar
K. P. Mohanakumar
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. P. Mohanakumar .

Editor information

Editors and Affiliations

Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan
Dinesh Chandra Agrawal
Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA
Muralikrishnan Dhanasekaran

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Remya, V.R., Chandra, G., Mohanakumar, K.P. (2019). Edible Mushrooms as Neuro-nutraceuticals: Basis of Therapeutics. In: Agrawal, D., Dhanasekaran, M. (eds) Medicinal Mushrooms. Springer, Singapore. https://doi.org/10.1007/978-981-13-6382-5_2

Download citation

DOI: https://doi.org/10.1007/978-981-13-6382-5_2
Published: 14 May 2019
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-6381-8
Online ISBN: 978-981-13-6382-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

Publish with us

Policies and ethics