Abstract
Genotoxicity can be defined as the toxic changes on the genetic material (DNA, RNA) of the cell leading to destruction of nucleotide strand breakage. Genotoxins are the mutagens and cause genotoxicity by damaging chromosomal material causing mutation. Genotoxins includes both chemical substance and radiation. Genetic material damage in somatic cells may lead to malignancy whereas damage in germ cells may lead to heritable mutations causing various birth defects. Therefore, assessment of genotoxicity is important for evaluation of safety aspects of substances for protection of health and the environment. The results of the genotoxicity tests form the scientific basis for risk assessment and are used for classification and labelling of chemical substances.
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Patra, J.K., Das, S.K., Das, G., Thatoi, H. (2019). Genotoxicity and Toxicological Studies. In: A Practical Guide to Pharmacological Biotechnology. Learning Materials in Biosciences. Springer, Singapore. https://doi.org/10.1007/978-981-13-6355-9_4
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DOI: https://doi.org/10.1007/978-981-13-6355-9_4
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