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Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities

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Aldehyde Dehydrogenases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1193))

Abstract

Aldehyde dehydrogenase 2 (ALDH2) is an important member of the functional aldehyde dehydrogenases (ALDHs) family in human beings, playing a fundamental role in the detoxification of acetaldehyde and other aldehydes. In recent years, a number of researches have given attention to the association between ALDH2 and atherosclerosis, which provided insights on targeting ALDH2 for therapeutic intervention of atherosclerosis. In this review, these inspiring studies will be discussed, and the clinical implications and concerns will be expounded.

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Abbreviations

4-HNE:

4-hydroxy-2-nonenal

ALDH2:

Aldehyde dehydrogenase 2

ALDHs:

Aldehyde dehydrogenases

apoE−/− :

Apolipoprotein E knockout

ASCVD:

Atherosclerotic cardiovascular disease

CABG:

Coronary artery bypass grafting

CVD:

Cardiovascular disease

EMP:

Empagliflozin

ER:

Endoplasmic reticulum

HDL-C:

High-density lipoprotein cholesterol

HUVECs:

Human umbilical vein endothelial cells

I/R injury:

Ischemia-reperfusion injury

LDL-C:

Low-density lipoprotein cholesterol

MDA:

Malondialdehyde

MI:

Myocardial infarction

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Author information

Authors and Affiliations

  1. Department of Cardiology, & National Clinical Research Center of Geriatrics Disease, Chinese PLA General Hospital, Beijing, China

    Sai Ma & Feng Cao

  2. Jinling Hospital Department of Cardiology, Nanjing University, School of Medicine, Nanjing, China

    Sai Ma

Authors
  1. Sai Ma
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  2. Feng Cao
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Jun Ren

  2. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Yingmei Zhang

  3. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Junbo Ge

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Ma, S., Cao, F. (2019). Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities. In: Ren, J., Zhang, Y., Ge, J. (eds) Aldehyde Dehydrogenases. Advances in Experimental Medicine and Biology, vol 1193. Springer, Singapore. https://doi.org/10.1007/978-981-13-6260-6_12

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