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Strategies for the Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids

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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

Abstract

ω-3 Fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) produce hydroxylated metabolites that mediate anti-inflammatory and pro-resolving actions. Such metabolites are categorized as E-series and D-series resolvins, protectins, and maresins. Herein, we summarize the syntheses of these metabolites reported up to mid-2018, focusing on the strategy and stereoselectivity in the construction of conjugated olefins and hydroxy-bearing carbons. Sections focus on conjugated triene, diene, and tetraene. Selectivity and yields are specified whenever possible.

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Acknowledgments

Our works have been supported by JSPS KAKENHI (Grant Numbers 23116507, 25116709, 15H05904), Kobayashi International Scholarship, and Takeda International Contribution Award.

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  1. Department of Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan

    Yuichi Kobayashi & Masao Morita

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  1. Yuichi Kobayashi
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Correspondence to Yuichi Kobayashi .

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  1. Department of Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

    Yuichi Kobayashi

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Kobayashi, Y., Morita, M. (2019). Strategies for the Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids. In: Kobayashi, Y. (eds) Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules. Springer, Singapore. https://doi.org/10.1007/978-981-13-6244-6_9

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