Abstract
Metabolism is a series of biochemical processes in living organisms that either produces or consumes energy. Generally, cellular metabolism in the virus-infected cells is altered to support virus growth and survival. In nature, the antiviral molecules generated during marine invertebrate stress responses to virus infection function to maintain or restore the metabolic homeostasis of host cells. As well known, tumorigenesis is accompanied with metabolic disturbance, which shares certain similarities in metabolic disorder of organisms with virus infection. Thus, the antiviral molecules may contribute to the antitumor effects in human being by maintaining or restoring the disordered metabolism of tumor cells to the normal metabolic homeostasis. MicroRNAs (miRNAs) have been identified as master regulators of many cellular processes including metabolism and virus infection, which can present different expression profiles and function as antiviral molecules by maintaining the metabolic homeostasis of host cells during virus infection. Besides, a miRNA possesses multiple target genes and can conduct the same or similar functions in different animal species by targeting various mRNAs. Therefore, miRNAs produced in the marine invertebrate stress responses to virus infection may take effects on tumorigenesis of human being.
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Gong, Y., Cui, Y., Zhang, X. (2019). Effects of MicroRNAs from Marine Invertebrate Stress Responses to Virus Infection on Tumorigenesis. In: Zhang, X. (eds) Virus Infection and Tumorigenesis. Springer, Singapore. https://doi.org/10.1007/978-981-13-6198-2_8
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DOI: https://doi.org/10.1007/978-981-13-6198-2_8
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