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Pleiotropic Protective Effects of Progranulin in the Treatment of Ischemic Stroke

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Book cover Progranulin and Central Nervous System Disorders

Abstract

Stroke is one of the leading causes of morbidity and mortality in the world. The majority of strokes is ischemic. Unfortunately, there is still not well substantial treatment option to increase the survival and alleviate the outcome after ischemic stroke. In the central nervous system, progranulin (PGRN) is considered to play important roles in the maintenance of physiological functions. Mutations in the gene that encodes PGRN cause transactive response DNA-binding protein 43-positive frontotemporal lobar degeneration. Several studies have reported that PGRN exerts protective effects against ischemic brain injury. PGRN alleviates the impairments after acute focal cerebral ischemia by a variety of mechanisms, which we call “brain protection”. This includes neuroprotection, suppression of neuroinflammation, and attenuation of blood-brain barrier disruption, i.e., vascular protection. PGRN has pleiotropic protective effects and is, therefore, an ideal candidate molecule for the therapy of stroke. We will accelerate the research towards further development of PGRN-based treatments of stroke.

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Author information

Authors and Affiliations

  1. Department of Neurology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan

    Masato Kanazawa

  2. Midori Hospital, Niigata, Japan

    Kunio Kawamura

  3. Department of Neurology, Nishi-Niigata Chuo Hospital, Niigata, Japan

    Tetsuya Takahashi

  4. Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan

    Takayoshi Shimohata

Authors
  1. Masato Kanazawa
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  2. Kunio Kawamura
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  3. Tetsuya Takahashi
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  4. Takayoshi Shimohata
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Corresponding author

Correspondence to Masato Kanazawa .

Editor information

Editors and Affiliations

  1. Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

    Hideaki Hara

  2. Dementia Research Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Masato Hosokawa

  3. Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

    Shinsuke Nakamura

  4. Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan

    Takayoshi Shimohata

  5. Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

    Masugi Nishihara

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Kanazawa, M., Kawamura, K., Takahashi, T., Shimohata, T. (2019). Pleiotropic Protective Effects of Progranulin in the Treatment of Ischemic Stroke. In: Hara, H., Hosokawa, M., Nakamura, S., Shimohata, T., Nishihara, M. (eds) Progranulin and Central Nervous System Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-6186-9_10

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