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Protection and Prevention of Age-Related Hearing Loss

  • Zu-hong He
  • Ming Li
  • Sheng-yu Zou
  • Fu-ling Liao
  • Yan-yan Ding
  • Hong-guo Su
  • Xin-feng Wei
  • Chun-jiang Wei
  • Yu-rong Mu
  • Wei-Jia KongEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1130)

Abstract

Presbycusis is a sensorineural hearing loss caused by hearing system aging and degeneration. The clinical manifestations are progressive bilateral symmetrical hearing loss, and the hearing curve is mostly slope-shaped with high-frequency reduction, sometimes flat. The results of the second national sample survey of disabled persons (2006) showed that the total number of hearing and speech disability in China was 27.8 million, accounting for 34% of the total number of disabled people in China. Among them are people over 60 years old. There are 20.4541 million people with hearing disabilities. There are 9.49 million senile deaf patients, accounting for 34.1% of the total number of hearing disabilities. As society gradually becomes aging, the incidence of presbycusis is getting higher and higher. The study of its pathogenesis is of great significance for the diagnosis, treatment, and prevention of presbycusis. The rapid progress of molecular biology experimental technology has provided us with a new opportunity to fully understand and reveal the presbycusis. In the near future, early diagnosis of presbycusis-related genes and early prevention or delay of the occurrence and development of presbycusis will become a reality.

Keywords

Presbycusis Etiology Pathology Diagnosis Treatment 

References

  1. 1.
    Olofsson J (2012) A new phase of European archives of oto-rhino-laryngology and head & neck. Eur Arch Otorhinolaryngol 269:2019–2020CrossRefGoogle Scholar
  2. 2.
    Huang Q, Tang J (2010) Age-related hearing loss or presbycusis. Eur Arch Otorhinolaryngol 267:1179–1191CrossRefGoogle Scholar
  3. 3.
    Mulrow CD, Aguilar C, Endicott JE, Tuley MR, Velez R, Charlip WS et al (1990) Quality-of-life changes and hearing impairment. A randomized trial. Ann Intern Med 113:188CrossRefGoogle Scholar
  4. 4.
    Andrea C, Chiara B, Stefano P, Antonio P (2012) The impact of hearing loss on the quality of life of elderly adults. Clin Interv Aging 2012:159Google Scholar
  5. 5.
    Bovo R, Ciorba A, Martini A (2011) Environmental and genetic factors in age-related hearing impairment. Aging Clin Exp Res 23:3–10CrossRefGoogle Scholar
  6. 6.
    Ciorba A, Benatti A, Bianchini C, Aimoni C, Volpato S, Bovo R et al (2011) High frequency hearing loss in the elderly: effect of age and noise exposure in an Italian group. J Laryngol Otol 125:776–780CrossRefGoogle Scholar
  7. 7.
    Tremblay K, Ross B (2007) Effects of age and age-related hearing loss on the brain. J Commun Disord 40:305–312CrossRefGoogle Scholar
  8. 8.
    Ha-Sheng LK (2012) Age-related hearing loss: quality of care for quality of life. Gerontologist 52:265–271CrossRefGoogle Scholar
  9. 9.
    Gates GA, Schmid P, Kujawa SG, Nam BH, D’Agostino R (2000) Longitudinal threshold changes in older men with audiometric notches. Hear Res 141:220–228CrossRefGoogle Scholar
  10. 10.
    Clinkard D, Amoodi H, Kandasamy T, Grewal AS, Chen S, Qian W et al (2014) Changes in the cochlear vasculature and vascular endothelial growth factor and its receptors in the aging c57 mouse cochlea. ISRN Otolaryngol 430625:2013Google Scholar
  11. 11.
    Pujol R, Rebillard G, Puel JL, Lenoir M, Eybalin M, Recasens M (1990) Glutamate neurotoxicity in the cochlea: a possible consequence of ischaemic or anoxic conditions occurring in ageing. Acta Otolaryngol 111:32–36CrossRefGoogle Scholar
  12. 12.
    Godfrey DA, Chen K, O'Toole TR, Mustapha AIAA (2017) Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats. Hear Res 350:173–188CrossRefGoogle Scholar
  13. 13.
    Zhong Y, Hu YJ, Chen B, Peng W, Sun Y, Yang Y et al (2011) Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging. FEBS J 278:2500–2510CrossRefGoogle Scholar
  14. 14.
    Tavanai E, Mohammadkhani G (2017) Role of antioxidants in prevention of age-related hearing loss: a review of literature. Eur Arch Otorhinolaryngol 274:1–14CrossRefGoogle Scholar
  15. 15.
    Böttger EC, Schacht J (2013) The mitochondrion: a perpetrator of acquired hearing loss. Hear Res 303:12–19CrossRefGoogle Scholar
  16. 16.
    Wu X, Wang Y, Sun Y, Chen S, Zhang S, Shen L et al (2014) Reduced expression of connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose. Biochem Biophys Res Commun 452:340–346CrossRefGoogle Scholar
  17. 17.
    Gratton MA, Smyth BJ, Lam CF, Boettcher FA, Schmiedt RA (1997) Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils. Hear Res 108:9–16CrossRefGoogle Scholar
  18. 18.
    Roth TN (2015) Aging of the auditory system. Handb Clin Neurol 129:357–373CrossRefGoogle Scholar
  19. 19.
    Eckert MA, Cute SL, Vaden KI Jr, Kuchinsky SE, Dubno JR (2012) Auditory cortex signs of age-related hearing loss. J Assoc Res Otolaryngol 13:703–713CrossRefGoogle Scholar
  20. 20.
    Schuknecht HF, (1964) Further observations on the pathology of presbycusis. Arch Otolaryngol Head Neck Surg 80(4):369–382Google Scholar
  21. 21.
    Schuknecht HF, Gacek MR (1993) Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol 102:1–16CrossRefGoogle Scholar
  22. 22.
    Jr RDF (2000) Neural substrates for presbycusis: anatomy, chemistry, and neuroimaging of the central auditory system. J Acoust Soc Am 107:2798Google Scholar
  23. 23.
    Mills DM, Schmiedt RA (2004) Metabolic presbycusis: differential changes in auditory brainstem and otoacoustic emission responses with chronic furosemide application in the gerbil. J Assoc Res Otolaryngol 5:1–10CrossRefGoogle Scholar
  24. 24.
    Schmiedt RA (2010) The physiology of cochlear presbycusisCrossRefGoogle Scholar
  25. 25.
    Ohlemiller KK (2004) Age-related hearing loss: the status of Schuknecht's typology. Curr Opin Otolaryngol Head Neck Surg 12:439CrossRefGoogle Scholar
  26. 26.
    Gates GA, Mills JH (2005) Presbycusis. Lancet 366:1111–1120CrossRefGoogle Scholar
  27. 27.
    Doungkamol S, Paul M, Philip N, Maryanne G, Elena R, George R (2003) Prevalence and characteristics of tinnitus in older adults: the Blue Mountains Hearing Study. Int J Audiol 42:289CrossRefGoogle Scholar
  28. 28.
    Song JJ, Ridder DD, Schlee W, Heyning PVD, Vanneste S (2013) “Distressed aging”: the differences in brain activity between early- and late-onset tinnitus. Neurobiol Aging 34:1853–1863CrossRefGoogle Scholar
  29. 29.
    Weij Kong LZ (2015) Binq Wang et. Presbycusis. People’s medical publishing houseGoogle Scholar
  30. 30.
    Liu CQ, Cheng XT, Zhu YH, Shen WD, Bian BW, Cao JY et al (2015) Clinical observation on hearing conditions of centenarians in northern district of China. Acta Otolaryngol 135:451–458CrossRefGoogle Scholar
  31. 31.
    Wang RL, Zhang DM (2017) The comparison of clinical features and laboratory indexes between flat descending hearing loss and total hearing loss. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 31:1892–1895PubMedGoogle Scholar
  32. 32.
    Gates GA, Cooper JC (1991) Incidence of hearing decline in the elderly[J]. Acta Otolaryngol 111(2):240–248Google Scholar
  33. 33.
    Mom T (2007) Otoacoustic emissions in clinical and surgical practice. Ann Otolaryngol Chir Cervicofac 124:80–89CrossRefGoogle Scholar
  34. 34.
    van Beeck Calkoen EA, Merkus P, Goverts ST, van de Kamp JM, Mulder MF, Sanchez Aliaga E et al (2018) Evaluation of the outcome of CT and MR imaging in pediatric patients with bilateral sensorineural hearing loss. Int J Pediatr Otorhinolaryngol 108:180–185CrossRefGoogle Scholar
  35. 35.
    Verschuur CA, Dowell A, Syddall HE, Ntani G, Simmonds SJ, Baylis D et al (2012) Markers of inflammatory status are associated with hearing threshold in older people: findings from the Hertfordshire Ageing Study. Age Ageing 41:92–97CrossRefGoogle Scholar
  36. 36.
    Alonso-Lujan LR, Gutierrez-Farfan I, Luna-Reyes FA, Chamlati-Aguirre LE, Durand Rivera A (2014) Audiometric evaluation short and medium term in cochlear implants. Rev Investig Clin 66:415–421Google Scholar
  37. 37.
    Musiek FE, Bornstein SP (1992) Contemporary aspects of diagnostic audiology. Am J Otolaryngol 13:23–33CrossRefGoogle Scholar
  38. 38.
    Herdman AT, Stapells DK (2003) Auditory steady-state response thresholds of adults with sensorineural hearing impairments. Int J Audiol 42:237–248CrossRefGoogle Scholar
  39. 39.
    Tunkel DE, Bauer CA, Sun GH, Rosenfeld RM, Chandrasekhar SS, Cunningham ER Jr et al (2014) Clinical practice guideline: tinnitus executive summary. Otolaryngol Head Neck Surg 151:533–541CrossRefGoogle Scholar
  40. 40.
    Song JJ, An GS, Choi I, De Ridder D, Kim SY, Choi HS et al (2016) Objectification and differential diagnosis of vascular pulsatile tinnitus by transcanal sound recording and spectrotemporal analysis: a preliminary study. Otol Neurotol 37:613–620CrossRefGoogle Scholar
  41. 41.
    Olsen WO, Rose DE, Hedgecock LD (2003) A brief history of audiology at Mayo Clinic. J Am Acad Audiol 14:173–180PubMedGoogle Scholar
  42. 42.
    Paul A, Marlin S, Parodi M, Rouillon I, Guerlain J, Pingault V et al (2017) Unilateral sensorineural hearing loss: medical context and etiology. Audiol Neurootol 22:83–88CrossRefGoogle Scholar
  43. 43.
    Kurien M, Thomas K, Bhanu TS (1989) Hearing threshold in patients with diabetes mellitus. J Laryngol Otol 103:164–168CrossRefGoogle Scholar
  44. 44.
    Sun AH, Li JY, Xiao SZ, Li ZJ, Wang TY (1990) Changes in the cochlear iron enzymes and adenosine triphosphatase in experimental iron deficiency. Ann Otol Rhinol Laryngol 99:988CrossRefGoogle Scholar
  45. 45.
    Niu X, Canlon B (2002) Protective mechanisms of sound conditioning. Adv Otorhinolaryngol 59:96–105PubMedGoogle Scholar
  46. 46.
    Han C, Ding D, Lopez MC, Manohar S, Zhang Y, Kim MJ et al (2016) Effects of long-term exercise on age-related hearing loss in mice. J Neurosci 36:11308CrossRefGoogle Scholar
  47. 47.
    Lotfi Y, Mehrkian S, Moossavi A, Faghih-Zadeh S (2009) Quality of life improvement in hearing-impaired elderly people after wearing a hearing aid. Arch Iran Med 12:365–370PubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Zu-hong He
    • 1
  • Ming Li
    • 1
  • Sheng-yu Zou
    • 1
  • Fu-ling Liao
    • 1
  • Yan-yan Ding
    • 1
  • Hong-guo Su
    • 1
  • Xin-feng Wei
    • 1
  • Chun-jiang Wei
    • 1
  • Yu-rong Mu
    • 1
  • Wei-Jia Kong
    • 1
    Email author
  1. 1.Department of Otorhinolaryngology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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