Epidermal Signaling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses
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In this chapter, we focused on the introduction of epidermal signaling pathways involved in the control of toxicity of environmental toxicants or stresses. We first introduced epidermal molecular signaling pathways, including insulin signaling pathway, peroxidase SKPO-1, collagens, SNF-12-STA-2 signaling cascade, G-protein-coupled receptors (GPCRs), and G proteins, in the regulation of toxicity of environmental toxicants or stresses. The potential effects of epidermal signals on other tissues or organs, such as neurons and intestine, were further introduced and discussed.
KeywordsEpidermal signaling pathway Environmental exposure Caenorhabditis elegans
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