Neuronal Signaling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses
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In this chapter, we focused on the introduction of important roles of neuronal signaling pathways in regulating the toxicity of environmental toxicants or stresses in nematodes. We first introduced and discussed the functions of neuronal MAPK signaling pathways (JNK and ERK MAPKs), TGF-β signaling pathway (both DAF-7- and DBL-1-mediated TGF-β signaling pathways), G-protein-coupled receptors (GPCRs) and G proteins, and neuropeptide proteins in the regulation of toxicity of environmental toxicants or stresses. Moreover, the effects of neuronal signals (INS-7, XBP-1, dopamine and serotonin signals, and Wnt signaling) on functions of molecular signals in other tissues or organs (especially the intestine) in the regulation of toxicity of environmental toxicants or stresses were further introduced and discussed.
KeywordsNeuronal signaling pathway Environmental exposure Caenorhabditis elegans
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