Abstract
Defining the true of skin pathologies non-invasively is still an unsolved problem for the dermatology community. In this study, a new noninvasive method to visualize skin pathologies using polarized light imaging is discussed. This technology will assist doctors as well as dermatologists in making a quick assessment of skin pathologies. Researching on the propagation of polarized light in randomly scattering media have been investigated as a new and a huge potential methodology for disease early detection. Accordingly, a fundamental understanding of how polarized light propagates through tissue is essential for the development clinically useful optical diagnostic systems because of its practical application, especially in non-invasive diagnosis. The purpose of this research concentrated on the interaction of polarized light and biological tissues utilizing Mueller matrix and Stokes parameter description for extracting nine optical parameters such as linear birefringence (LB), linear dichroism (LD), circular birefringence (CB), circular dichroism (CD), linear depolarization (L-Dep), and circular depolarization (C-Dep) properties. The samples of the healthy skin and the non-melanoma skin cancer extracted from mouse were analyzed and compared their effective optical characterization. The experimental results illustrated that the LB and LD of the disease samples tend to be larger than the standard samples, creating an innovating solid foundation for the diagnosis of skin cancer in the future.
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References
de Boer, J.F., Milner, T.E., van Gemert, M.J., Nelson, J.S.: Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography. Opt. Lett. 22(12), 934–936 (1997)
Maitland, D.J., Walsh, J.T.: Quantitative measurements of linear birefringence during heating of native collagen. Lasers Surg. Med. 20(3), 310–318 (1997)
Wu, P.J., Walsh, J.T.: Stokes polarimetry imaging of rat tail tissue in a turbid medium: degree of linear polarization image maps using incident linearly polarized light. J. Biomed. Opt. 11(1), 14031 (2006)
Sun, P., Ma, Y., Liu, W., Yang, Q., Jia, Q.: Mueller matrix decomposition for determination of optical rotation of glucose molecules in turbid media. J. Biomed. Opt. 19(4), 46015 (2014)
Kelly, S.M., Jess, T.J., Price, N.C.: How to study proteins by circular dichroism. Biochim. Biophys. Acta Proteins Proteomics 1751(2), 119–139 (2005)
Swords, N.A., Wallace, B.A.: Circular-dichroism analyses of membrane proteins: examination of environmental effects on bacteriorhodopsin spectra. Biochem. J. 289(Pt 1), 215–219 (1993)
Angelskaya, A., Gruia, I., Yermolenko, S., Ivashko, P., Gruia, M.: Manifestations of linear dichroism changes in cancer biotissues. Rom. Reports Phys. 65(3), 1052–1062 (2013)
Wang, W., Lim, L.G., Srivastava, S., Yan, J.S.B., Shabbir, A., Liu, Q.: Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples. J. Biomed. Opt. 19(4), 46020 (2014)
Wood, M.F.G., Guo, X., Vitkin, I.A.: Polarized light propagation in multiply scattering media exhibiting both linear birefringence and optical activity: Monte Carlo model and experimental methodology. J. Biomed. Opt. 12(1), 14029 (2007)
Ghosh, N., Wood, M.F.G., Vitkin, I.A.: Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence. J. Biomed. Opt. 13(4), 44036 (2008)
Pham, T.-T.-H., Lo, Y.-L.: Extraction of effective parameters of anisotropic optical materials using decoupled analytical method. J. Biomed. Opt. 17(2), 25006-1-25006-17 (2012)
Pham, T.-T.-H., Lo, Y.-L.: Extraction of effective parameters of turbid media utilizing the Mueller matrix approach: study of glucose sensing. J. Biomed. Opt. 17(9), 0970021–09700215 (2012)
Pham, H.-T.-T., Nguyen, A.L.-T., Vo, T.-V., Huynh, K.-C., Phan, Q.-H.: Optical parameters of human blood plasma, collagen, and calfskin based on the Stokes-Mueller technique. Appl. Opt. 57(16), 4353–4359 (2018)
Acknowledgements
The authors gratefully acknowledge the financial support provided to this study by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 103.03-2016.86
Conflict of Interest The authors declare that they have no conflict of interest.
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Le, D.L., Huynh, T.N., Pham, TTH. (2020). Characterization of Non-melanoma Skin Cancer Utilizing the Optical Polarizing System. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore. https://doi.org/10.1007/978-981-13-5859-3_69
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DOI: https://doi.org/10.1007/978-981-13-5859-3_69
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