Abstract
Moisturizing ability makes hydrogel wound dressing the optimal treatment for dry wound, but this feature also creates a convenient environment for proliferation of microorganisms. The loading of silver nanoparticles (AgNPs), which exhibit wide-spectrum antimicrobial activity, into the wound dressing helps counter this problem. However, a hydrogel matrix with suitable properties is required to maintain the size and activity of AgNPs as well as control their release kinetic. Here this research formulated hydrogel composites from polyvinyl alcohol (PVA) and chitosan (Cs) loading with AgNPs and initially examined their qualities. Microwave irradiation was used to synthesize AgNPs by reducing silver nitrate and crosslink PVA with Cs. Based on its sensitive crosslinking behavior, the concentration of PVA was varied in the composition to investigate its effect on the characteristics of the hydrogels. Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA) were performed to observe the interaction between the components of the hydrogels and the change in thermal property of the hydrogels caused by this variation.
Ngoc Thi-thanh Nguyen and Nam Minh-phuong Tran—contributed equally.
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This research is funded by Vietnam National University HoChiMinh City (VNU-HCM) under grant number C2018-28-02.
Conflict of Interest The authors declare that they have no conflict of interest.
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Nguyen, N.Tt., Tran, N.Mp., Nguyen, TH. (2020). Effect of Polyvinyl Alcohol Concentration on Properties of Polyvinyl Alcohol-Chitosan Hydrogel Loading Silver Nanoparticles. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore. https://doi.org/10.1007/978-981-13-5859-3_54
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