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Diffuse Large B-Cell Lymphoma

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Ocular Adnexal Lesions

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Abstract

Among the non-Hodgkin’s B-cell lymphomas, diffuse large B-cell lymphoma (DLBCL) is one of the high grade lymphoma types. They occur less frequently compared to MALT and follicular lymphomas. High-grade lymphomas have systemic disease in addition to the ocular adnexa, relapse frequently, and exhibit poor survival rates. DLBCL is also associated with an increased risk of involvement of the central nervous system (CNS). The most common intraocular lymphoma is DLBCL, and it is usually associated with CNS involvement. It has diverse clinical presentations and outcomes, depending on genetic and phenotypic profiling.

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Further Reading

  1. Cani AK, Soliman M, Hovelson DH, et al. Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88 and chromatin modifiers: new routes to targeted therapies. Mod Pathol. 2016;29(7):685–97.

    Article  CAS  Google Scholar 

  2. Coupland SE. Molecular pathology of lymphoma. Eye (Lond). 2013;27(2):180–9.

    Article  CAS  Google Scholar 

  3. Ponzoni M, Govi S, Licata G, et al. A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma. Oncologist. 2013;18(7):876–84.

    Article  Google Scholar 

  4. Zarrabi K, Desai V, Yim B, Gabig TG. Primary diffuse large B-cell lymphoma localized to the lacrimal sac: a case presentation and review of the literature. Case Rep Hematol. 2016;2016:5612749.

    PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, National University Hospital, Singapore, Singapore

    Shantha Amrith, Stephanie Ming Young & Gangadhara Sundar

  2. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Shantha Amrith, Stephanie Ming Young & Gangadhara Sundar

  3. Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore

    Eric Ting

  4. Department of Diagnostic Imaging, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Eric Ting

  5. Advanced Medicine Imaging, Singapore, Singapore

    Eric Ting

  6. Department of Pathology, National University Hospital, Singapore, Singapore

    Bingcheng Wu & Min En Nga

  7. Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Min En Nga

Authors
  1. Shantha Amrith
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  2. Stephanie Ming Young
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  3. Eric Ting
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  4. Bingcheng Wu
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  5. Min En Nga
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  6. Gangadhara Sundar
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Corresponding author

Correspondence to Shantha Amrith .

Editor information

Editors and Affiliations

  1. National University Hospital, National University of Singapore, Singapore, Singapore

    Shantha Amrith

  2. National University Hospital, National University of Singapore, Singapore, Singapore

    Gangadhara Sundar

  3. National University Hospital, National University of Singapore, Singapore, Singapore

    Stephanie Ming Young

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© 2019 Springer Nature Singapore Pte Ltd.

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Amrith, S., Young, S.M., Ting, E., Wu, B., Nga, M.E., Sundar, G. (2019). Diffuse Large B-Cell Lymphoma. In: Amrith, S., Sundar, G., Young, S. (eds) Ocular Adnexal Lesions. Springer, Singapore. https://doi.org/10.1007/978-981-13-3798-7_37

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  • DOI: https://doi.org/10.1007/978-981-13-3798-7_37

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-3797-0

  • Online ISBN: 978-981-13-3798-7

  • eBook Packages: MedicineMedicine (R0)

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