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Ocular Adnexal Lesions pp 161–165Cite as

Ossifying Fibromyxoid Tumour

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Abstract

Myxoid soft tissue neoplasms of the face and orbit may present in non-specific patterns with symptoms depending on affected structures. These are mesenchymal neoplasms characterized by the production of abundant extracellular myxoid matrix that can be categorized as benign or malignant. Among them, ossifying fibromyxoid tumour is a rare form with borderline malignant potential. Around 70% is said to arise from extremities and would occasionally involve the trunk, head and neck, oral cavity, mediastinum, and retroperitoneum. It has been reported in only 150 cases in literature, rarely in the orbit, with the first case being reported in 2006.

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Further Reading

  1. Al-Mazrou KA, Mansoor A, Payne M, Richardson MA. Ossifying fibromyxoid tumor of the ethmoid sinus in a newborn: report of a case and literature review. Int J Pediatr Otorhinolaryngol. 2004;68(2):225–30.

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  2. Baheti AD, Tirumani SH, Rosenthal MH, Howard SA, Shinagare AB, Ramaiya NH, Jagannathan JP. Myxoid soft-tissue neoplasms: comprehensive update of the taxonomy and MRI features. Am J Roentgenol. 2015;204(2):374–85.

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  3. Bakiratharajan D, Rekhi B. Ossifying fibromyxoid Tumor: an update. Arch Pathol Lab Med. 2016;140(4):371–5.

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  4. Binesh F, Akhavan A, Navabii H. Ossifying fibromyxoid tumour: a rare soft tissue tumour of intermediate malignancy. BMJ Case Rep. 2011;2011:bcr0820103263.

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  5. Endo M, Kohashi K, Yamamoto H, Ishii T, Yoshida T, Matsunobu T, Iwamoto Y, Oda Y. Ossifying fibromyxoid tumor presenting EP400-PHF1 fusion gene. Hum Pathol. 2013;44(11):2603–8.

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  6. Folpe AL, Weiss SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27(4):421–31.

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  7. Kilpatrick WGW, Mozes M, Miettinen M, Fukunaga M, Fletcher CDM. Atypical and malignant variants of ossifying fibromyxoid tumor: clinicopathologic analysis of six cases. Am J Surg Pathol. 1995;19(9):1039–46.

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  8. Kondylidou-Sidira A, Kyrgidis A, Antoniades H, Antoniades K. Ossifying fibromyxoid tumor of head and neck region: case report and systematic review of literature. J Oral Maxillofac Surg. 2011;69(5):1355–60.

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  9. Nonaka CF, Pacheco DF, Nunes RP, Freitas Rde A, Miguel MC. Ossifying fibromyxoid tumor in the mandibular gingiva: case report and review of the literature. J Periodontol. 2009;80(4):687–92.

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  10. Park DJ, Miller NR, Green WR. Ossifying fibromyxoid tumor of the orbit. Ophthalmic Plast Reconstr Surg. 2006;22(2):87–91.

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  11. Sharma K, Hughes D, Harper RD. Ossifying fibromyxoid tumor (OFMT) – a rare cause of a painful thumb. Int J Surg Case Rep. 2015;7C:93–5.

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  12. Velasco AV, Zhang R, Li T, Wang D. Ossifying fibromyxoid tumor of soft parts in head and neck: case report and literature review. Diagn Pathol. 2018;13:21.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, National University Hospital, Singapore, Singapore

    Mariel Angelou Parulan, Shantha Amrith, Stephanie Ming Young & Gangadhara Sundar

  2. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Shantha Amrith, Stephanie Ming Young & Gangadhara Sundar

  3. Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore

    Eric Ting

  4. Department of Diagnostic Imaging, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Eric Ting

  5. Advanced Medicine Imaging, Singapore, Singapore

    Eric Ting

  6. Department of Pathology, National University Hospital, Singapore, Singapore

    Bingcheng Wu & Min En Nga

  7. Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Min En Nga

Authors
  1. Mariel Angelou Parulan
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  2. Shantha Amrith
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  3. Stephanie Ming Young
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  4. Eric Ting
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  5. Bingcheng Wu
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  6. Min En Nga
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  7. Gangadhara Sundar
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Corresponding author

Correspondence to Shantha Amrith .

Editor information

Editors and Affiliations

  1. National University Hospital, National University of Singapore, Singapore, Singapore

    Shantha Amrith

  2. National University Hospital, National University of Singapore, Singapore, Singapore

    Gangadhara Sundar

  3. National University Hospital, National University of Singapore, Singapore, Singapore

    Stephanie Ming Young

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Parulan, M.A. et al. (2019). Ossifying Fibromyxoid Tumour. In: Amrith, S., Sundar, G., Young, S. (eds) Ocular Adnexal Lesions. Springer, Singapore. https://doi.org/10.1007/978-981-13-3798-7_30

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  • DOI: https://doi.org/10.1007/978-981-13-3798-7_30

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-3797-0

  • Online ISBN: 978-981-13-3798-7

  • eBook Packages: MedicineMedicine (R0)

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