Applications of Polyhydroxyalkanoates Based Nanovehicles as Drug Carriers

Sugappriya, Mohanasundaram; Sudarsanam, Dorairaj; Joseph, Jerrine; Mir, Mudasir A.; Selvaraj, Chandrabose

doi:10.1007/978-981-13-3759-8_6

Applications of Polyhydroxyalkanoates Based Nanovehicles as Drug Carriers

Mohanasundaram Sugappriya²,
Dorairaj Sudarsanam³,
Jerrine Joseph⁴,
Mudasir A. Mir⁵ &
…
Chandrabose Selvaraj⁶

Chapter
First Online: 25 January 2019

1218 Accesses
2 Citations

Abstract

Polyhydroxyalkanoates (PHAs) are the biodegradable polyesters synthesized from the bacterial origin with high therapeutic importance due to their major biopolymer properties like biodegradability, biocompatibility, non-toxicity and thermo-plasticity. These hypotheses make the PHAs as one of the drug carrier or nanovehicles for therapeutic drug delivery. Drug delivery is one of the emerging fields in biological science, which gives application of delivering the promising drug molecules in the desired drug target, with increasing dissolution rate and bioavailability. Understanding the drug-polymer interactions and controlled release makes the combo of the perfect drug molecule and the biopolymer, and in this, the PHA is reported to be a better natural origin drug carrier. Several reports suggest that, chemical entities of PHA show enhanced activity and used as one of the promising nanocarrier. Experimental test by several assays shows PHA’s as one of the compatible biopolymers in tissues. This chapter comes up with various applications related to PHAs like medical implants, adhesion barriers, drug carriers, tissue engineering, Nano based targeted delivery. Overall, this chapter will provide a perfect base for studies on PHA related to drug carrier studies.

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Abbreviations

APTS:: para-toluene sulfonic acid monohydrate
DTXL:: Docetaxel
HA:: hydroxyapatite
HDI:: 1,6-hexamethylene di-isocyanate
P3:: poly(esterurethane)s
P3HB4HB:: poly(R-3-hydroxybutyrate-co-4-hydroxybutyrate)
P4HB:: poly-4-hydroxybutyrate;
PHA(s):: Polyhydroxyalkanoate(s)
PhaP:: amphiphilic PHA granule binding protein
PhaR:: PHA synthesis repressor protein
PHB:: poly-(R)-3-hydroxybutyrate;
PHB:: Polyhydroxybutyrate
PHBHHx:: poly(R-3-hydroxybutyrate-co-R-3-hydroxyhexanoate)
PHBHx:: Poly(hydroxybutyrate-co-hydroxyhexanoate)
PHBO:: Poly(hydroxybutyrate-co-hydroxyoctanoate)
PHBV:: Poly(hydroxybutyrate-co-hydroxyvalerate)
PHBV:: poly(R-3-hydroxybutyrate-co-R-3-hydroxyvalerate)
PHBVHHx:: poly(R-3-hydroxy-butyrate-co-R-3-hydroxyvalerate-co-R-3-hydroxyhexanoate)
PHHx:: Poly(hydroxyhexanoate)
PHHx:: Poly(hydroxyhexanoate)
PHO:: Poly(hydroxyoctanoate)
PHO:: poly-(R)-3-hydroxyoctanoate;
PPC:: Poly propylene carbonate

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Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India
Mohanasundaram Sugappriya
Department of Zoology and Advanced Biotechnology, Loyola College, Chennai, Tamil Nadu, India
Dorairaj Sudarsanam
Centre for Drug Discovery and Development, Jeppiaar Research Park, Sathyabama Deemed to be University, Chennai, Tamil Nadu, India
Jerrine Joseph
Centre for Plant Biotechnology, Division of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, India
Mudasir A. Mir
School of Basic Science, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India
Chandrabose Selvaraj

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Mohanasundaram Sugappriya
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Dorairaj Sudarsanam
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Jerrine Joseph
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Mudasir A. Mir
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Chandrabose Selvaraj
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Department of Chemical Engineering, Konkuk University, Seoul, Korea (Republic of)
Vipin Chandra Kalia

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Sugappriya, M., Sudarsanam, D., Joseph, J., Mir, M.A., Selvaraj, C. (2019). Applications of Polyhydroxyalkanoates Based Nanovehicles as Drug Carriers. In: Kalia, V. (eds) Biotechnological Applications of Polyhydroxyalkanoates. Springer, Singapore. https://doi.org/10.1007/978-981-13-3759-8_6

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Published: 25 January 2019
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