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Poor Early Growth and Age-Associated Disease

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Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Part of the book series: Subcellular Biochemistry ((SCBI,volume 91))

Abstract

The prevalence of age-associated disease is increasing at a striking rate globally and there is evidence to suggest that the ageing process may actually begin before birth. It has been well-established that the status of both the maternal and early postnatal environments into which an individual is exposed can have huge implications for the risk of developing age-associated disease, including cardiovascular disease (CVD), type-2 diabetes (T2D) and obesity in later life. Therefore, the dissection of underlying molecular mechanisms to explain this phenomenon, known as ‘developmental programming’ is a highly investigated area of research. This book chapter will examine the epidemiological evidence and the animal models of suboptimal maternal and early postnatal environments and will discuss the progress being made in the development of safe and effective intervention strategies which ultimately could target those ‘programmed’ individuals who are known to be at-risk of age-associated disease.

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Authors and Affiliations

  1. University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Treatment Centre, Addenbrooke’s Hospital, Cambridge, UK

    Jane L. Tarry-Adkins & Susan E. Ozanne

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  1. Jane L. Tarry-Adkins
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  2. Susan E. Ozanne
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Editors and Affiliations

  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. Newcastle University, Newcastle upon Tyne, UK

    Viktor I. Korolchuk

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Tarry-Adkins, J.L., Ozanne, S.E. (2019). Poor Early Growth and Age-Associated Disease. In: Harris, J., Korolchuk, V. (eds) Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Subcellular Biochemistry, vol 91. Springer, Singapore. https://doi.org/10.1007/978-981-13-3681-2_1

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