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Molecular Basis for Reduced Lifespan Induced by Environmental Toxicants or Stresses

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Molecular Toxicology in Caenorhabditis elegans

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Abstract

What’s the potential basic principle for the toxicity induction on different endpoints in nematodes exposed to environmental toxicants or stresses? To answer such a question, we here focus on the endpoint of lifespan to discuss the potential basic principle for toxicity induction from environmental toxicants or stresses. In this chapter, we will discuss how the environmental toxicants or stresses reduce lifespan by affecting the molecular basis for longevity, and how the innate immune response is involved in the regulation of longevity reduction in nematodes exposed to environmental toxicants or stresses. We will further introduce the genetic identification of genes and signaling cascade in the regulation of toxicity of environmental toxicants or stresses. We will also discuss how the environmental toxicants or stresses reduce lifespan by affecting signaling pathways associated with the stress response.

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  1. School of Medicine, Southeast University, Nanjing, China

    Dayong Wang

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Wang, D. (2019). Molecular Basis for Reduced Lifespan Induced by Environmental Toxicants or Stresses. In: Molecular Toxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-3633-1_2

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