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Genetic Aspect of Allied Disorders of Hirschsprung’s Disease

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Hirschsprung’s Disease and the Allied Disorders

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Abstract

Allied disorders of Hirschsprung’s disease (ADHD) have been proposed to be the concept of the functional obstruction of the intestine with the presence of ganglion cells in the terminal rectum. Coordinated action of the enteric nervous system (ENS), interstitial cells of Cajal (ICC), and smooth muscle cells (SMCs) is indispensable to normal gastrointestinal motility. Developmental defects affecting specific cell types or disturbing proper functioning of the ENS, ICC, or SMCs may result in variable degrees of abnormal motility, eventually leading to the development of intestinal neuromuscular disorders. In this chapter, we will discuss an overview of genetics of ADHD.

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Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan

    Kosuke Kirino & Koichiro Yoshimaru

Authors
  1. Kosuke Kirino
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  2. Koichiro Yoshimaru
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Correspondence to Kosuke Kirino .

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Editors and Affiliations

  1. Department of Pediatric Surgery, Kyushu University, Fukuoka, Fukuoka, Japan

    Tomoaki Taguchi

  2. Department of Pediatric Surgery, St. Luke’s International Hospital, Chuo-Ku, Tokyo, Japan

    Hiroshi Matsufuji

  3. Department of Pediatric Surgery, Kagoshima University, Kagoshima, Kagoshima, Japan

    Satoshi Ieiri

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Kirino, K., Yoshimaru, K. (2019). Genetic Aspect of Allied Disorders of Hirschsprung’s Disease. In: Taguchi, T., Matsufuji, H., Ieiri, S. (eds) Hirschsprung’s Disease and the Allied Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-3606-5_35

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  • DOI: https://doi.org/10.1007/978-981-13-3606-5_35

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-3605-8

  • Online ISBN: 978-981-13-3606-5

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