History of Allied Hirschsprung’s Disease
Hirschsprung’s disease shows transit disorder of intestinal content, delayed meconium excretion, abdominal distention, bilious vomiting, constipation, and intestinal dilatation (megacolon) at proximal side, resulting from aperistalsis and lack of the recto-anal reflex caused by aganglionosis of the distal segment. In the pediatric surgery field, the disease has been widely recognized, the condition has been elucidated, and the therapy has been developed. In these clinical and research settings, there is a disease group which has symptoms and laboratory findings similar to those of Hirschsprung’s disease despite the presence of ganglion cells in the rectum. It has been called “allied Hirschsprung’s disease” in Japan. However, the disease concept and diseases included in the group have been changed over time, and a consensus is not yet established among specialists.
KeywordsAllied Hirschsprung’s disease Pseudo-Hirschsprung’s disease Hirschsprung’s disease-related neuromuscular disorders of the intestine
- 2.Bebley FFR, Nixon HH, Ehrenpreis TH, et al. Seminar on pseudo-Hirschsprung’s and related disorders. Arch Dis Child. 1966;42:143.Google Scholar
- 5.Rode H, Brown RA, Nummanoglu A. Degenerative hollow visceral myopathy. In: Holschneider AM, editor. Hirschsprung’s and allied disorders. 3rd ed. Prem Puri: Springer; 2006. p. 275–85.Google Scholar
- 6.Muto M, Matsufuji H, Muranaga F, et al. Data mined distinctive features of pediatric chronic idiopathic intestinal pseudo-obstruction in Japan. Pediatric Therapeut. 2015;5:1.Google Scholar