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Mitophagy, Diseases, and Aging

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Models, Molecules and Mechanisms in Biogerontology

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Abstract

Mitochondrial dysfunction contributes to age-associated disease phenotypes and aging. With age, mitochondria show change in morphology, mutation and change in mtDNA, increase in oxidative stress, epigenetic change in mitochondrial proteins, and defect in mitochondrial quality control leading to accumulation of dysfunctional mitochondria. Mitophagy, a specified form of autophagy, regulates the turnover of damaged and dysfunctional mitochondria to govern energy homeostasis. The age-dependent impairment of mitophagy inhibits removal of superfluous or dysfunctional mitochondria as well as weakens the biogenesis of mitochondria resulting in the aggregation of reactive mitochondrial mass and consequently leads to the deterioration of cellular function. Novel therapeutic strategies have been articulated for maintaining healthy mitophagy level which could delay aging and extend health span. This chapter provides an updated mechanistic overview of mitophagy pathways and discusses the effect of mitophagy in aging.

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Acknowledgments

Research support was partly provided by the Department of Biotechnology (DBT) [Number: BT/PR7791/BRB/10/1187/2013] and Science and Engineering Research Board (SERB) [Number: EMR/2016/001246], Department of Science and Technology.

Conflict of Interest Statement

The authors have declared no conflict of interest.

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Authors and Affiliations

  1. Department of Life Science, National Institute of Technology, Rourkela, India

    Sujit K. Bhutia, Debasna P. Panigrahi, Chandra S. Bhol & Kewal K. Mahapatra

  2. Department of Zoology, Vikram Deb (Autonomous) College, Jeypore (K), Odisha, India

    Prajna P. Naik

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  1. Sujit K. Bhutia
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  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Pramod C. Rath

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Bhutia, S.K., Naik, P.P., Panigrahi, D.P., Bhol, C.S., Mahapatra, K.K. (2019). Mitophagy, Diseases, and Aging. In: Rath, P. (eds) Models, Molecules and Mechanisms in Biogerontology. Springer, Singapore. https://doi.org/10.1007/978-981-13-3585-3_9

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