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Association Between Ageing and REM Sleep Loss: Noradrenaline Acting as a Mediator

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Models, Molecules and Mechanisms in Biogerontology

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Abstract

Rapid eye movement sleep (REMS) constitutes a distinct and unique stage within sleep, which is essential for the maintenance of normal physiological processes. It is maximum in the babies, reduces with increased age, and is expressed least in the old age. REMS loss is associated with various pathophysiological disorders; expressions of several of the symptoms are common with those associated with ageing. As many of those common symptoms are induced by elevated levels of noradrenaline in the brain, we propose that the ageing-associated symptoms could be due to REMS loss and consequent increase in noradrenaline in the brain.

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Abbreviations

AD:

Alzheimer’s disease

aDMRs:

Ageing-associated differentially methylated regions

GABA:

Gamma-aminobutyric acid

LC:

Locus coeruleus

NA:

Noradrenaline

NREMS:

Non-REMS

PD:

Parkinson’s disease

REMS:

Rapid eye movement sleep

REMSD:

REMS deprivation

ROS:

Reactive oxygen species

SD:

Sleep deprivation

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Acknowledgments

RM received DST-WOSA fellowship. AK received CSIR and BUILDER (DBT) fellowship. Research funding to BNM through institutional support under BUILDER (DBT), PURSE (DST), UPOE II (UGC), DRS (UGC), and grants from UGC and J C Bose fellowship are acknowledged.

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All authors contributed toward preparing this manuscript.

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Authors and Affiliations

  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Rachna Mehta, Awanish Kumar & Birendra Nath Mallick

  2. Amity Institute of Neuropsychology and Neurosciences, Amity University, Noida, India

    Rachna Mehta

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  1. Rachna Mehta
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  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Pramod C. Rath

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Mehta, R., Kumar, A., Mallick, B.N. (2019). Association Between Ageing and REM Sleep Loss: Noradrenaline Acting as a Mediator. In: Rath, P. (eds) Models, Molecules and Mechanisms in Biogerontology. Springer, Singapore. https://doi.org/10.1007/978-981-13-3585-3_6

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