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Molecular Connection Between Diabetes and Dementia

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Diabetes Mellitus

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1128))

Abstract

Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) are both serious global health problems with high prevalence. These two diseases have some common features, including risk factors, age-associated disease onsets, insulin resistance, impaired glucose metabolism, deregulation of O-GlcNAcylation, chronic oxidative stress, and inflammation. Some of these features, such as insulin resistance, impaired glucose metabolism, and deregulation of O-GlcNAcylation, may serve as molecular links between T2DM and AD. Research on these molecular links is reviewed and discussed in this chapter. Understanding of these molecular links will help uncover the disease mechanisms and design therapeutic strategies to prevent and treat these two devastating diseases.

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Acknowledgments

This work was supported in part by the New York State Office for People with Developmental Disabilities (Staten Island, New York, USA), the Second Affiliated Hospital, School of Medicine, Zhejiang University (Hangzhou, China), and a research grant from the Natural Science Foundation of China (81400866).

Conflict of Interest

C.-X.G. serves on the scientific advisory board of Alectos Therapeutics and filed a patent application dealing with O-GlcNAcylation treatment for ischemic brain injury. Y.C. and C.-X.G. hold a patent on the prevention of anesthesia-induced memory loss by using intranasal insulin. The other author confirms that this article content has no conflicts of interest.

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Authors and Affiliations

  1. Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Yanxing Chen

  2. Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA

    Yanxing Chen, Qian Yu & Cheng-Xin Gong

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  1. Yanxing Chen
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  2. Qian Yu
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  3. Cheng-Xin Gong
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Correspondence to Cheng-Xin Gong .

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  1. Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    Yusaku Nakabeppu

  2. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Toshiharu Ninomiya

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Chen, Y., Yu, Q., Gong, CX. (2019). Molecular Connection Between Diabetes and Dementia. In: Nakabeppu, Y., Ninomiya, T. (eds) Diabetes Mellitus. Advances in Experimental Medicine and Biology, vol 1128. Springer, Singapore. https://doi.org/10.1007/978-981-13-3540-2_6

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