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Preventive Oncology for the Gynecologist pp 315–331Cite as

Vaginal Intraepithelial Neoplasia (VaIN): Diagnosis and Management

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Abstract

Vaginal intraepithelial neoplasia (VaIN) is a relatively uncommon and asymptomatic preneoplastic lesion associated with human papillomavirus (HPV) of the lower genital tract. The diagnosis is usually suspected with abnormal cervical-vaginal cytology and confirmed by punch biopsy. The treatment of VaIN varies depending on several factors including grade of the dysplasia, location, and extent of lesions, patients’ characteristics including age and onset of HPV infection, and previous therapeutic procedures. The four main treatment methods include surgery, ablation, topical therapies, and radiation (brachytherapy). All treatments have reasonably good success but are limited by their unique side effects, and all are associated with some risk for recurrence. Patients require long-term monitoring to survey for recurrence or progression to vaginal cancer. HPV vaccination is a promising strategy to reduce the incidence of VaIN and vaginal cancer.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

    Xingnan Zhou

  2. Department of Pathology, Florida Hospital Orlando, Orlando, FL, USA

    Tien Anh Nguyen Tran

  3. Florida Hospital Gynecologic Oncology, Orlando, FL, USA

    Robert W. Holloway

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  1. Xingnan Zhou
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  2. Tien Anh Nguyen Tran
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  3. Robert W. Holloway
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Babu Jagjivan Ram Memorial Hospital, New Delhi, India

    Sumita Mehta

  2. Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India

    Anshuja Singla

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Zhou, X., Tran, T.A.N., Holloway, R.W. (2019). Vaginal Intraepithelial Neoplasia (VaIN): Diagnosis and Management. In: Mehta, S., Singla, A. (eds) Preventive Oncology for the Gynecologist. Springer, Singapore. https://doi.org/10.1007/978-981-13-3438-2_25

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  • DOI: https://doi.org/10.1007/978-981-13-3438-2_25

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  • Publisher Name: Springer, Singapore

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  • Online ISBN: 978-981-13-3438-2

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