Management of Vulvar Intraepithelial Neoplasia

  • Divya Pandey
  • Sumita Mehta


Vulvar intraepithelial neoplasia (VIN) is a premalignant condition of the vulva, which is increasingly becoming common especially during the fifth decade of life. As per the latest ISSVD (International Society for the Study of Vulvovaginal Disease) terminology, HSIL (high-grade squamous intraepithelial lesion) and dVIN (differentiated vulvar intraepithelial neoplasia) can develop into invasive cancer. The diagnosis of HSIL and dVIN can be done using biopsy of suspicious lesions or by identifying abnormal areas using vulvoscopy and confirming by taking biopsy of acetowhite lesions. Treatment depends upon the number and site of lesions and includes options like wide local excision, skinning vulvectomy, laser ablation and topical immune-modulator therapy.


Vulval intraepithelial lesions HSIL dVIN Vulvoscopy Skinning vulvectomy Topical imiquimod Topical cidofovir Photodynamic therapy 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Divya Pandey
    • 1
  • Sumita Mehta
    • 2
  1. 1.Department of Obstetrics and GynecologyVardhman Mahavir Medical College and Safdarjung HospitalNew DelhiIndia
  2. 2.Department of Obstetrics and GynecologyBabu Jagjivan Ram Memorial HospitalNew DelhiIndia

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