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Intravenous Thrombolysis

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Abstract

Acute ischemic stroke is a leading cause of disability worldwide. It is caused by a thrombus that blocks the flow of blood in a vessel of the brain. Early reperfusion therapy to restore blood flow by lysing the thrombus may reduce the volume of cerebral tissue irreversibly damaged. Intravenous thrombolytic drugs, particularly alteplase, have become the standard of treatment in acute ischemic stroke. With various randomized trials and increasing level of evidence, the eligibility criteria for the use of intravenous alteplase have been streamlined, thereby reducing the risks associated with this therapy, most notably symptomatic intracranial hemorrhage.

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Authors and Affiliations

  1. Department of Neuroanesthesiology and Critical Care, Medanta, The Medicity, Gurgaon, India

    Vasudha Singhal & Jaya Wanchoo

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  1. Vasudha Singhal
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  2. Jaya Wanchoo
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Editors and Affiliations

  1. Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India

    Hemanshu Prabhakar

  2. Division of Neuroanesthesiology, Department of Anesthesiology, Sher-i-Kashmir Institute of Medical Sciences Soura, Srinagar, Jammu and Kashmir, India

    Zulfiqar Ali

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Singhal, V., Wanchoo, J. (2019). Intravenous Thrombolysis. In: Prabhakar, H., Ali, Z. (eds) Textbook of Neuroanesthesia and Neurocritical Care. Springer, Singapore. https://doi.org/10.1007/978-981-13-3387-3_25

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  • DOI: https://doi.org/10.1007/978-981-13-3387-3_25

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