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Sepsis-Induced Lung Injury: The Mechanism and Treatment

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Abstract

Sepsis-induced lung injury is one of the severest complications in sepsis. It belongs to the category of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). On the basis of both experimental and clinical studies, the pathogenesis of sepsis-induced lung injury includes the contributions of inflammatory response, vascular hyperpermeability, alveolar edema accumulation, and ventilator-induced lung injury. Survival has been increased with the strategy of protective ventilation based on a ventilator. However, specific effective pharmacologic therapies are still lacking, in spite of the tests of some anti-inflammatory and anticoagulant agents. As new therapeutic strategies, cell therapy and gene therapy are still in their infancy, and their potentials remain to be evaluated. Although a number of basic studies show that some traditional Chinese medicines can protect against ALI or ARDS, it still needs to be further verified by clinical trials.

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Authors and Affiliations

  1. Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China

    Gui Xiao & Xianzhong Xiao

  2. Department of International School of Nursing, Hainan Medical University, Haikou, Hainan, China

    Gui Xiao

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  1. Gui Xiao
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  2. Xianzhong Xiao
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Correspondence to Xianzhong Xiao .

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  1. Wound Healing and Cell Biology Lab, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, China

    Xiaobing Fu

  2. State Key Laboratory of Trauma, Burns, and Combined Injury, Daping Hospital, Third Military Medical University, Chong Qing, China

    Liangming Liu

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Xiao, G., Xiao, X. (2019). Sepsis-Induced Lung Injury: The Mechanism and Treatment. In: Fu, X., Liu, L. (eds) Severe Trauma and Sepsis. Springer, Singapore. https://doi.org/10.1007/978-981-13-3353-8_15

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