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Salvage Surgery in Post-radiotherapy/Chemoradiation in Carcinoma of the Larynx and Hypopharynx

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Carcinoma of the Larynx and Hypopharynx

Abstract

Radiotherapy alone is the standard care of treatment for early disease of the larynx and hypopharynx. Similarly, cisplatin-based chemoradiation is an established treatment strategy for organ preservation in select moderately advanced lesions [1–4]. However, nearly 40% of cases are diagnosed with residual or recurrent locoregional disease after chemoradiation [5].

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References

  1. Forastiere AA, Coepfert H, Maor M, et al. Concurrent chemo-therapy and radio-therapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349:2091–8.

    Article  CAS  PubMed  Google Scholar 

  2. Wolf GT, Hong WK. Induction chemotherapy for organ preservation in advanced laryngeal cancer: is there a role? Head Neck. 1995;17:279–83.

    Article  CAS  PubMed  Google Scholar 

  3. Lefebvre JL, Chevalier D, Luboinski B, et al. Larynx preservation in pyriform sinus cancer; preliminary results of a European Organisation for research and treatment of cancer phase III trial. EURTC Head and Neck Cancer Co-operative Group. J Natl Cancer Inst. 1996;88:890–9.

    Article  CAS  PubMed  Google Scholar 

  4. Lefebvre JL, Rolland F, Tresselar M, et al. Phase III randomized trial on larynx preservation comparing sequential versus alternating chemotherapy and radiotherapy. J Natl Cancer Inst. 2009;101:142–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Van-Der Putten L, De Bree R, Doornaert PA, et al. Salvage surgery in post-chemo-radiotherapy laryngeal and hypopharyngeal carcinoma: outcome and review. Acta Otorhinolaryngol Ital. 2015;35:162–72.

    Google Scholar 

  6. Sandro J, Stoeckli SJ, Pawlik AB, Margereta L, et al. Salvage surgery after failure of non-surgical therapy for carcinoma of the larynx and hypopharynx. Arch Otolaryngol Head Neck Surg. 2000;126:1473–7.

    Article  Google Scholar 

  7. Bahadur S, Amatya RC, Kackar SK. Enigma of post-radiotherapy oedema in diagnosis of residual or recurrent disease of larynx and pyriform fossa. J Laryngol Otol. 1985;99:763–5.

    Google Scholar 

  8. Brandenburg JH, Condon KG, Frank W. Coronal sections of larynges from radiation therapy failures: a clinical pathologic study. Otolaryngol Head Neck Surg. 1986;95:213–8.

    Article  CAS  PubMed  Google Scholar 

  9. Suzuki K, Hayashi R, Ebihara M, et al. The effectiveness of chemo-radiation therapy and salvage surgery for hypopharyngeal squamous cell carcinoma. Jpn J Clin Oncol. 2013;43:1210–7.

    Article  PubMed  Google Scholar 

  10. Supriano G, Pellini R, Romano G, et al. Supracricoid partial laryngectomy as salvage surgery after radiation failure. Head Neck. 2002;24:759–63.

    Article  Google Scholar 

  11. Nibu K, Kamata S, Kawabata K, et al. Partial laryngectomy in treatment of radiation failure of early glottic carcinoma. Head Neck. 1997;19:116–20.

    Article  CAS  PubMed  Google Scholar 

  12. Lydiatt WM, Shah JP, Lydiatt KM. Conservation surgery for recurrent carcinoma of the glottic larynx. Am J Surg. 1996;172:662–4.

    Article  CAS  PubMed  Google Scholar 

  13. Biller HF, Barnhill FR, Ogura JH. Hemilaryngectomy for radiation failure for carcinoma of vocal cord. Laryngoscope. 1970;80:249.

    Article  CAS  PubMed  Google Scholar 

  14. Walters GW, Patel SG, Rhys-Evans PH. Partial laryngectomy for recurrent laryngeal carcinoma. Clin Otolaryngol Allied Sci. 2000;25:146–52.

    Article  Google Scholar 

  15. Ganly I, Patel S, Matsuo J, et al. Post-operative complications of salvage total laryngectomy. Cancer. 2005;103:2073–81.

    Article  PubMed  Google Scholar 

  16. Weber RS, Berkey BA, Forastiere A, et al. Outcome of salvage total laryngectomy following organ preservation therapy. The radiation therapy oncology trial 91-11. Arch Otolaryngol Head Neck Surg. 2003;129:44–9.

    Article  PubMed  Google Scholar 

  17. Sarkar S, Mehta SA, Tiwari J, et al. Complications following surgery for carcinoma of the larynx and pyriform fossa. J Surg Oncol. 1990;43:245–9.

    Article  CAS  PubMed  Google Scholar 

  18. Johanson IV, Overgaard O, Elbrond O. Pharyngocutaneous fistula after laryngectomy Influence of previous radiotherapy and prophylactic metronidazole. Cancer. 1988;61:673–8.

    Article  Google Scholar 

  19. Bahadur S, Amatya RC, Kacker SK, Madan N. Etiology and management of pharyngocutaneous fistulae following laryngectomy. Indian J Otolaryngol. 1985;37:1–3.

    Google Scholar 

  20. Davidson J, Keane T, Brown D, et al. Surgical salvage after radiotherapy for advanced laryngopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 1997;123:420–4.

    Article  CAS  PubMed  Google Scholar 

  21. Lavalle RJ, Maw AR. The etiology of post-laryngectomy pharyngocutaneous fistulae. J Laryngol Otol. 1972;86:785–93.

    Article  Google Scholar 

  22. Leon X, Qner M, Orns CL, et al. Results of salvage surgery for local or regional recurrence after larynx preservation with induction chemotherapy and radiotherapy. Head Neck. 2001;23:733–78.

    Article  CAS  PubMed  Google Scholar 

  23. Tan HK, Giger R, Auperin A, et al. Salvage surgery after concomitant chemo-radiation in head and neck squamous cell carcinomas – stratification for post-salvage survival. Head Neck. 2010;32:139–47.

    Article  CAS  PubMed  Google Scholar 

  24. Paydarfar JA, Birkmeyar NJ. Complications in head and neck surgery: a meta-analysis of post-laryngectomy pharyngocutaneous fistula. Arch Otolaryngol Head Neck Surg. 2006;132:67–72.

    Article  PubMed  Google Scholar 

  25. Panje WR, Namon AJ, Vokes E, et al. Surgical management of the head and neck cancer patient following concomitant multimodal therapy. Laryngoscope. 1995;105:97–101.

    Article  CAS  PubMed  Google Scholar 

  26. Lee JH, Marchtay M, Unger LD, et al. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124:871–5.

    Article  CAS  PubMed  Google Scholar 

  27. Smith TJ, Burrage KJ, Ganguli P, et al. Prevention of post laryngectomy pharyngocutaneous fistula: the Memorial University experience. J Otolaryngol. 2003;32:222–5.

    Article  PubMed  Google Scholar 

  28. Sayles M, Grant DG. Preventing pharyngocutaneous fistula in total laryngectomy: a systematic reviewed and meta-analysis. Laryngoscope. 2014;124:1150–63.

    Article  PubMed  Google Scholar 

  29. Paleri V, Drinnan M, Van den Brackel MW, et al. Vascularized flaps to reduce fistula following salvage total laryngectomy: a systemic review. Laryngoscope. 2014;124:1848–53.

    Article  PubMed  Google Scholar 

  30. Righini C, Lequeux T, van den Burg CD, et al. The pectoralis myofascial flap in pharyngolaryngeal surgery after radiotherapy. Eur Arch Otolaryngol. 2005;262:357–61.

    Article  CAS  Google Scholar 

  31. Tsou YA, Hua CH, Lin MH, et al. Comparison of pharyngocutaneous fistula between patients following by primary laryngopharyngectomy and salvage laryngopharyngectomy for advanced hypopharyngeal cancer. Head Neck. 2010;32:1494–500.

    Article  PubMed  Google Scholar 

  32. Withrow KP, Rosenthal EL, Gourin CG, et al. Free tissue transfer to manage salvage laryngectomy defects after organ preservation failure. Laryngoscope. 2007;117:781–4.

    Article  PubMed  Google Scholar 

  33. Relic A, Scheich M, Stapf J, et al. Salvage surgery after induction chemotherapy with paclitaxel/cisplatin and primary radiotherapy for advanced laryngeal and hypopharyngeal carcinoma. Eur Arch Otolaryngol. 2009;266:1799–180.

    Article  CAS  Google Scholar 

  34. Brokovich VS, Miller FR, Karnad AB, et al. Role of positron emission tomography scans in the management of the N Positive neck in head and neck carcinoma after radio-therapy. Laryngoscope. 2006;116:855–8.

    Article  Google Scholar 

  35. Parsons JT, Mendelhall WM, Stringer SP, et al. Salvage surgery following radiation failure in squamous cell carcinoma of the supraglottis larynx. Int J Radiat Oncol Biol Phys. 1995;32:605–9.

    Article  CAS  PubMed  Google Scholar 

  36. McLaughlin MP, Parson JT, Fein DA, et al. Salvage surgery after radiotherapy failure in T1-T2 squamous cell carcinoma of the glottis larynx. Head Neck. 1996;18:229–35.

    Article  CAS  PubMed  Google Scholar 

  37. Chambell BH, Goepfert H. Partial laryngectomy as a salvage procedure for radiation failure. In: Kagan AR, Miles J, editors. Head and neck oncology clinical management. New York: Pergamon Press Inc; 1989. p. 91–5.

    Google Scholar 

  38. The Department of Veterans Affairs Laryngeal Cancer Study Groups. Induction chemotherapy plus radiation compared with surgery and radiation in patients with advance laryngeal cancer. N Engl J Med. 1991;324:1685–90.

    Article  Google Scholar 

  39. Posner MR, Hershock DM, Blajman CR, et al. Cisplatin and fluorouracil alone or with decetaxel in head and neck cancer. N Engl J Med. 2007;357:1705–15.

    Article  CAS  PubMed  Google Scholar 

  40. Lefebvre JL. What is the role of primary surgery in the treatment of laryngeal and hypopharyngeal cancer? Arch Otolaryngol Head Neck Surg. 2000;126:285–8.

    Article  CAS  PubMed  Google Scholar 

  41. Lefebvre JL, Latigau E. Preservation of form and function during management of cancer of larynx and hypopharynx. World J Surg. 2003;27:811–6.

    Article  PubMed  Google Scholar 

  42. Hanna E, Sherman A, Cash D, et al. Quality of life for patients following total laryngectomy vs chemo-radiation for laryngeal preservation. Arch Otolaryngol Head Neck Surg. 2004;130:875–9.

    Article  PubMed  Google Scholar 

  43. Aaronson NK, Ahmedzai S, Bergman B, et al. European organisation for research and treatment of Cancer QLQC30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–76.

    Article  CAS  PubMed  Google Scholar 

  44. Bjordal K, Hammerlid E, Abiner Almqvisr M, et al. Quality of life in head and neck cancer patients: validation of the European Organisation for Research and Treatment Cancer Quality of life Questionnaire. H & N 35. J Clin Oncol. 1999;17:1008–19.

    Article  CAS  PubMed  Google Scholar 

  45. Guibert M, Lepage B, Woisard V, et al. Quality of life in patients treated for advanced hypopharyngeal or laryngeal cancer. Eur Ann Otolaryngol Head Neck. 2011;128:218–23.

    Article  CAS  Google Scholar 

  46. Boscolo-Rizzo P, Maranato F, Marchiori C, et al. Long term quality of life after total laryngectomy and post operative radiotherapy versus concurrent chemo-radiotherapy for laryngeal preservation. Laryngoscope. 2008;118:300–6.

    Article  PubMed  Google Scholar 

  47. Trivedi NP, Swaminathan DK, Thanakappan KK, et al. Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy. Otolaryngol Head Neck Surg. 2008;139:702–7.

    Article  PubMed  Google Scholar 

  48. El-Deiry M, Funk GF, Nalwa S, et al. Long term quality of life for surgical and non-surgical treatment of head and neck cancer. Arch Otolaryngol Head Neck Surg. 2005;131:879–85.

    Article  PubMed  Google Scholar 

  49. Ramirez MJ, Ferriol EE, Domenech FG, et al. Psychosocial adjustment in patients surgically treated for laryngeal cancer. Otolaryngol Head Neck Surg. 2003;129:92–7.

    Article  PubMed  Google Scholar 

  50. Terrel JE, Fisher SG, Wolf GT, The Veterans Affairs Laryngeal Cancer Study Group. Long term quality of life after treatment of laryngeal Cancer. Arch Otolaryngol Head Neck Surg. 1998;124:854–971.

    Google Scholar 

  51. Deleylannis FW, Weymuller EA Jr, Coltrera MD, et al. Quality of life after laryngectomy: are disabilities important? Head Neck. 1999;21:319–24.

    Article  Google Scholar 

  52. Morton RP, Izzard ME. Quality of Life outcomes in head and neck cancer patient’s. World J Surg. 2003;27:884–9.

    Article  PubMed  Google Scholar 

  53. de Graeff A, de Leepw JR, Ross WJ, et al. Long term quality of life of patients with head and neck cancer. Laryngoscope. 2000;110:98–106.

    Article  PubMed  Google Scholar 

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Bahadur, S. (2019). Salvage Surgery in Post-radiotherapy/Chemoradiation in Carcinoma of the Larynx and Hypopharynx. In: Bahadur, S., Thakar, A., Mohanti, B. (eds) Carcinoma of the Larynx and Hypopharynx . Springer, Singapore. https://doi.org/10.1007/978-981-13-3110-7_13

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  • DOI: https://doi.org/10.1007/978-981-13-3110-7_13

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