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Biochemical and Biophysical Roles of Cell Surface Molecules pp 163–175Cite as

Group I Metabotropic Glutamate Receptors (mGluRs): Ins and Outs

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1112))

Abstract

Glutamate is a nonessential amino acid, known to act as a major excitatory neurotransmitter in the central nervous system. Glutamate transduces its signal by activating two types of receptors, viz., ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs). mGluR1 and mGluR5 are members of the group I mGluR family, and they belong to the G-protein-coupled receptor (GPCR) family. These receptors are involved in various forms of synaptic plasticity including learning and memory. Similar to many other GPCRs, trafficking plays a critical role in controlling the spatiotemporal localization of these receptors on the cell surface, which is critical for the normal ligand/receptor interaction. Improper targeting of GPCRs results in aberrant signaling, which often leads to various diseases. Trafficking also regulates the activity of these receptors. Thus, inappropriate trafficking of these receptors might have pathological consequences. Group I mGluRs have been implicated in various neuropsychiatric disorders like Fragile X syndrome, autism, etc. In this review, we discuss the current understanding of group I mGluR trafficking in the central nervous system and its physiological importance.

Author contributed equally with all other contributors.Prabhat Kumar Mahato, Namrata Ramsakha, Prachi Ojha, Ravinder Gulia and Rohan Sharma

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    Authors and Affiliations

    1. Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, SAS Nagar, Punjab, India

      Prabhat Kumar Mahato, Namrata Ramsakha, Prachi Ojha, Ravinder Gulia, Rohan Sharma & Samarjit Bhattacharyya

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    1. Prabhat Kumar Mahato
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    2. Namrata Ramsakha
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    3. Prachi Ojha
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    4. Ravinder Gulia
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    5. Rohan Sharma
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    6. Samarjit Bhattacharyya
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    Correspondence to Samarjit Bhattacharyya .

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    1. Centre for Protein Science, Design and Engineering, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India

      Kausik Chattopadhyay

    2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA

      Subhash C. Basu

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    Mahato, P.K., Ramsakha, N., Ojha, P., Gulia, R., Sharma, R., Bhattacharyya, S. (2018). Group I Metabotropic Glutamate Receptors (mGluRs): Ins and Outs. In: Chattopadhyay, K., Basu, S. (eds) Biochemical and Biophysical Roles of Cell Surface Molecules. Advances in Experimental Medicine and Biology, vol 1112. Springer, Singapore. https://doi.org/10.1007/978-981-13-3065-0_12

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