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Next-Generation Sequencing for Genetic Diagnosis of Hereditary Colorectal Cancer and Polyposis Syndrome

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Recent Advances in the Treatment of Colorectal Cancer

Abstract

Approximately 5% of the total colorectal cancers are thought to be the hereditary ones. Phenotypes of the hereditary colorectal cancer and polyposis syndromes (HCCPS) as represented mainly by the Lynch syndrome and familial adenomatous polyposis overlap each other to some extent, making it difficult to provide a definite diagnosis, solely by the clinicopathological features. In order to cope with this issue, the genetic testing based on the next-generation sequencing techniques gathers much attention to the field of the HCCPS in recent years. In this chapter, the utility of the next-generation sequencing techniques and some tasks to be solved are discussed.

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Authors and Affiliations

  1. Diagnosis and Therapeutics of Intractable Diseases, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan

    Hidetaka Eguchi & Yasushi Okazaki

Authors
  1. Hidetaka Eguchi
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  2. Yasushi Okazaki
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Correspondence to Hidetaka Eguchi .

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Editors and Affiliations

  1. Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan

    Hideyuki Ishida

  2. Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan

    Keiji Koda

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Eguchi, H., Okazaki, Y. (2019). Next-Generation Sequencing for Genetic Diagnosis of Hereditary Colorectal Cancer and Polyposis Syndrome. In: Ishida, H., Koda, K. (eds) Recent Advances in the Treatment of Colorectal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-13-3050-6_10

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  • DOI: https://doi.org/10.1007/978-981-13-3050-6_10

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-3049-0

  • Online ISBN: 978-981-13-3050-6

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