Acute Kidney Injury: Transition to Chronic Kidney Disease

  • Daisuke Katagiri
  • Eisei NoiriEmail author
  • Ryo Matsuura
  • Raymond C. Harris


Acute kidney injury (AKI) is a syndrome characterized by rapid or sudden decrease in kidney function, often accompanied with oliguria, which happens within a few days. Restoration from AKI is not always simple. If it sustained or repeated, patient will potentially develop chronic kidney disease (CKD) in some days. The illness trajectory from AKI to CKD is more found in persistent type of AKI, transit to acute kidney diseases (AKD), in which kidney injury is ongoing. Here we describe a representative case of AKI after cisplatin treatment for chemotherapy for squamous cell carcinoma (SCC) which leads to CKD. This review discussed referring to the recent interpretation in this area clarifying the clinical evaluation point. Our experimental rodent model which develops CKD after cisplatin-induced AKI is also shown. The future strategy to close up the potential worsening cohort in AKI is proposed in combination with diagnosis and therapeutic intervention.


AKI Acute kidney diseases (AKD) cisplatin-induced AKI L-FABP, liver fatty acid binding protein VAP-1, vascular adhesion protein-1 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Daisuke Katagiri
    • 1
    • 2
    • 3
  • Eisei Noiri
    • 1
    Email author
  • Ryo Matsuura
    • 1
  • Raymond C. Harris
    • 2
  1. 1.Department of Nephrology and EndocrinologyUniversity Hospital, The University of TokyoTokyoJapan
  2. 2.Department of Hemodialysis and Apheresis, 107 LaboratoryUniversity Hospital, The University of TokyoTokyoJapan
  3. 3.Division of NephrologyVanderbilt University Medical CenterNashvilleUSA

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