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Cancer and Excess Iron

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Human Pathobiochemistry
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Abstract

A 62-year-old male presented transient loss of consciousness during dialysis and was transferred to the emergency room. Chest X-ray and computed tomography revealed prominent right pleural effusion with large tumor mass surrounding the contour of the right lung. The patient had been involved in demolition work of old buildings and water pipes for more than 25 years, where he was often exposed to asbestos fibers in the air. The patient suffered from diabetes mellitus for 18 years and started dialysis three times a week since 7 years ago due to diabetic nephropathy.

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References

  • Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S (2012) Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. PLoS One 7:e43403

    Article  CAS  Google Scholar 

  • Chew SH, Toyokuni S (2015) Malignant mesothelioma as an oxidative stress-induced cancer: an update. Free Radic Biol Med 86:166–178

    Article  CAS  Google Scholar 

  • Ebina Y, Okada S, Hamazaki S, Ogino F, Li JL, Midorikawa O (1986) Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum- nitrilotriacetate complexes in rats. J Natl Cancer Inst 76:107–113

    CAS  PubMed  Google Scholar 

  • Heesterbeek H, Anderson RM, Andreasen V, Bansal S, De Angelis D, Dye C, Eames KT, Edmunds WJ, Frost SD, Funk S (2015) Modeling infectious disease dynamics in the complex landscape of global health. Science 347:aaa4339

    Article  Google Scholar 

  • Hwang HC, Sheffield BS, Rodriguez S, Thompson K, Christopher HT, Gown AM, Churg A (2016) Utility of BAP1 immunohistochemistry and p16 (CDKN2A) FISH in the diagnosis of malignant mesothelioma in effusion cytology specimens. Am J Surg Pathol 40:120–126

    Article  Google Scholar 

  • IARC, WHO 2012. Asbestos (chrysotile, amosite, crocidolite, tremolite, actinolite, and anthophyllite). IARC monographs on the evaluation of carcinogenic risks to humans a review of human carcinogens; part C: arsenic, metals, fibres, and dusts. Lyon, France

    Google Scholar 

  • Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S (2012) Iron overload signature in chrysotile-induced malignant mesothelioma. J Pathol 228:366–377

    Article  CAS  Google Scholar 

  • Kato J, Miyanishi K, Kobune M, Nakamura T, Takada K, Takimoto R, Kawano Y, Takahashi S, Takahashi M, Sato Y, Takayama T, Niitsu Y (2007) Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C. J Gastroenterol 42:830–836

    Article  CAS  Google Scholar 

  • Nagai H, Ishihara T, Lee WH, Ohara H, Okazaki Y, Okawa K, Toyokuni S (2011a) Asbestos surface provides a niche for oxidative modification. Cancer Sci 102:2118–2125

    Article  CAS  Google Scholar 

  • Nagai H, Okazaki Y, Chew S, Misawa N, Yamashita Y, Akatsuka S, Yamashita K, Ishihara T, Yoshikawa Y, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S (2011b) Diameter of multi-walled carbon nanotubes is a critical factor in mesothelial injury and subsequent carcinogenesis. Proc Natl Acad Sci U S A 108:E1330–E1338

    Article  Google Scholar 

  • Ohara Y, Chew S-H, Shibata T, Okazaki Y, Yamashita K, Toyokuni S (2018) Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats. Cancer Sci 109(2):330–339

    Article  CAS  Google Scholar 

  • Oury TD, Sporn TA, Roggli VL (2014) Pathology of asbestos-associated diseases, 3rd edn. Springer-Verlag Berlin Heiderberg, New York

    Book  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2015) Cancer statistics, 2015. CA Cancer J Clin 65:5–29

    Article  Google Scholar 

  • Toyokuni S (1996) Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 20:553–566

    Article  CAS  Google Scholar 

  • Toyokuni S (1999) Reactive oxygen species-induced molecular damage and its applicaton in pathology. Pathol Int 49:91–102

    Article  CAS  Google Scholar 

  • Toyokuni S (2009a) Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci 71:1–10

    CAS  PubMed  Google Scholar 

  • Toyokuni S (2009b) Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci 100:9–16

    Article  CAS  Google Scholar 

  • Toyokuni S (2011) Iron as a target of chemoprevention for longevity in humans. Free Radic Res 45:906–917

    Article  CAS  Google Scholar 

  • Toyokuni S (2016) The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy. Pathol Int 66:245–259

    Article  CAS  Google Scholar 

  • Toyokuni S (2018) Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: toward the era of mesothelioma prevention. Free Radic Biol Med. https://doi.org/10.1016/j.freeradbiomed.2018.10.401

  • Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S (2017) Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis. Free Radic Biol Med 108:610–626

    Article  CAS  Google Scholar 

  • Weinberg R (2013) The biology of cancer. Garland Science, New York

    Google Scholar 

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Correspondence to Shinya Toyokuni .

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Toyokuni, S. (2019). Cancer and Excess Iron. In: Oohashi, T., Tsukahara, H., Ramirez, F., Barber, C., Otsuka, F. (eds) Human Pathobiochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-13-2977-7_19

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