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Systemic Diseases with an Increased Risk of Oral Squamous Cell Carcinoma

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Premalignant Conditions of the Oral Cavity

Part of the book series: Head and Neck Cancer Clinics ((HNCC))

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Abstract

There is a growing awareness of the important relationships between systemic inflammatory diseases, infections, genetic disorders, medical therapies and cancer risk. A number of systemic disorders have been associated with an increased risk of head and neck squamous cell carcinoma. These include autoimmune conditions, genetic syndromes, infections, iatrogenic causes such as haematopoietic stem cell transplantation and graft-versus-host disease and rare associations including novel drugs. This chapter will discuss conditions which confer an increased risk of head and neck squamous cell carcinoma, as well as review the evidence for diseases which have been historically associated with oral cancer.

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Authors and Affiliations

  1. Oral Medicine, Eastman Dental Hospital, University College London Hospitals NHS Trust, London, UK

    Martina K. Shephard

  2. Oral Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

    Esther A. Hullah

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  1. Martina K. Shephard
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  2. Esther A. Hullah
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Correspondence to Martina K. Shephard .

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  1. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Peter A. Brennan

  2. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Tom Aldridge

  3. Department of Otolaryngology, Head Neck Surgery, Queen Elizabeth University Hospital, Glasgow, UK

    Raghav C. Dwivedi

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© 2019 Peter A. Brennan, Tom Aldridge, Raghav C. Dwivedi, Rehan Kazi

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Shephard, M.K., Hullah, E.A. (2019). Systemic Diseases with an Increased Risk of Oral Squamous Cell Carcinoma. In: Brennan, P., Aldridge, T., Dwivedi, R. (eds) Premalignant Conditions of the Oral Cavity. Head and Neck Cancer Clinics. Springer, Singapore. https://doi.org/10.1007/978-981-13-2931-9_7

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