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Premalignant Conditions of the Oral Cavity pp 97–117Cite as

Oral Lichen Planus and the Lichenoid Group of Diseases

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Part of the book series: Head and Neck Cancer Clinics ((HNCC))

Abstract

According to available articles that investigated patients affected by OLP, it seems that only a very small rate of malignant transformation may occur in these chronic autoimmune disorders. However, the difficult reproducibility of lichen planus diagnosis, the short and irregular follow-up periods, the simultaneous use of risk factors for oral cancer, and the lack of a well-controlled prospective clinical study are some limitations that impair that any strong conclusion on the real potential for carcinomatous change of OLP is obtained. Moreover, these methodological limitations also avoid that possible predictive factors for OSCC development are found. Therefore, the main objective of future studies must be to obtain large samples of cases strictly selected based on current clinical and morphological criteria for diagnosing OLP, so that more reliable data can be provided and the controversial discussion on malignant transformation of OLP that already takes over a century can be better clarified. New biomarkers may also improve the diagnosis of OLP and better differentiate this lesion from its main differential diagnoses.

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Authors and Affiliations

  1. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Felipe Paiva Fonseca & Ricardo Santiago Gomez

  2. Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Peter A. Brennan

  3. Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil

    Hélder Antônio Rebelo Pontes

  4. Service of Oral Medicine, Sírio-Libanês Hospital, São Paulo, Brazil

    Eduardo Rodrigues Fregnani

  5. Department of Oral Diagnosis (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil

    Márcio Ajudarte Lopes & Pablo Agustin Vargas

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  1. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Peter A. Brennan

  2. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Tom Aldridge

  3. Department of Otolaryngology, Head Neck Surgery, Queen Elizabeth University Hospital, Glasgow, UK

    Raghav C. Dwivedi

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Fonseca, F.P. et al. (2019). Oral Lichen Planus and the Lichenoid Group of Diseases. In: Brennan, P., Aldridge, T., Dwivedi, R. (eds) Premalignant Conditions of the Oral Cavity. Head and Neck Cancer Clinics. Springer, Singapore. https://doi.org/10.1007/978-981-13-2931-9_6

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