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The Molecular Basis of Carcinogenesis

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Premalignant Conditions of the Oral Cavity

Part of the book series: Head and Neck Cancer Clinics ((HNCC))

Abstract

In this chapter, we will discuss the molecular basis of carcinogenesis. First understand, and then treat! Better treatment options for cancer and preventive approaches for potentially malignant lesions can be achieved only if the pathobiology of the disease is well understood. We have witnessed a shift in the therapeutic approaches to cancer, from “universal” therapies applied to several different tumour types to tailored and personalized treatment. Each tumour/lesion is unique. As the understanding of malignant transformation and carcinogenesis requires knowledge of molecular and tumour biology, we aim to discuss carcinogenesis initially in a broader context before discussing the effects of carcinogens on the aetiology of potentially malignant oral lesions.

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Author information

Authors and Affiliations

  1. Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil

    Carolina Cavalieri Gomes

  2. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil

    Marina Gonçalves Diniz & Ricardo Santiago Gomez

Authors
  1. Carolina Cavalieri Gomes
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  2. Marina Gonçalves Diniz
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  3. Ricardo Santiago Gomez
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Corresponding author

Correspondence to Carolina Cavalieri Gomes .

Editor information

Editors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Peter A. Brennan

  2. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Tom Aldridge

  3. Department of Otolaryngology, Head Neck Surgery, Queen Elizabeth University Hospital, Glasgow, UK

    Raghav C. Dwivedi

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© 2019 Peter A. Brennan, Tom Aldridge, Raghav C. Dwivedi, Rehan Kazi

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Gomes, C.C., Diniz, M.G., Gomez, R.S. (2019). The Molecular Basis of Carcinogenesis. In: Brennan, P., Aldridge, T., Dwivedi, R. (eds) Premalignant Conditions of the Oral Cavity. Head and Neck Cancer Clinics. Springer, Singapore. https://doi.org/10.1007/978-981-13-2931-9_2

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  • DOI: https://doi.org/10.1007/978-981-13-2931-9_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2930-2

  • Online ISBN: 978-981-13-2931-9

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