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Diagnostic Value of Fractional Exhaled Nitric Oxide (FeNO)

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Advances in Asthma

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Abstract

Asthma is a heterogeneous disease, usually characterized by chronic inflammation of the airways. Fractional nitric oxide (NO) concentration in exhaled air (FeNO) is recognized as a noninvasive biomarker of eosinophilic inflammation in the lower respiratory tract. Presence of airway inflammation in addition to respiratory symptoms that are suggestive of asthma supports a diagnosis of asthma. This chapter provides recent topics pertaining to asthma including the mechanism of production of NO in the airway, methods of and interpretations in measuring FeNO, and the role of exhaled NO measurement in making diagnosis of asthma and differentiating asthma from chronic obstructive pulmonary disease (COPD).

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Abbreviations

ACO:

Asthma-COPD overlap

COPD:

Chronic obstructive pulmonary disease

eNOS:

Endothelial nitric oxide synthase

FeNO:

Fractional nitric oxide concentration in exhaled air

FEV1:

Forced expiratory volume in one second

FVC:

Forced vital capacity

iNOS:

Inducible nitric oxide synthase

NO:

Nitric oxide

nNOS:

Neuronal nitric oxide synthase

ROS:

Reactive oxygen species

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Authors and Affiliations

  1. Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube, Japan

    Kazuto Matsunaga

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  1. Kazuto Matsunaga
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Correspondence to Kazuto Matsunaga .

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Editors and Affiliations

  1. Department of Hematology and Respiratory Medicine, Kochi Medical School, Nankoku-shi, Kochi, Japan

    Akihito Yokoyama

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Matsunaga, K. (2019). Diagnostic Value of Fractional Exhaled Nitric Oxide (FeNO). In: Yokoyama, A. (eds) Advances in Asthma. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-13-2790-2_9

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  • DOI: https://doi.org/10.1007/978-981-13-2790-2_9

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2789-6

  • Online ISBN: 978-981-13-2790-2

  • eBook Packages: MedicineMedicine (R0)

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