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Group 2 Innate Lymphoid Cells and Asthma

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Abstract

Group 2 innate lymphoid cells (ILC2s) do not express antigen-specific receptors or lineage-specific surface markers but produce large amounts of Th2 cytokines in response to interleukin (IL)-25 and IL-33 secreted from bronchial epithelial cells stimulated with protease-based allergens or infection with microorganisms. The number of ILC2s are increased and activated in the peripheral blood and airways of patients with asthma, especially with severe and/or eosinophilic forms. Corticosteroids can induce ILC2 apoptosis; however, these cells acquire corticosteroid resistance through activation of the Janus kinase/signal transducer and activator of transcription 5 pathway by thymic stromal lymphopoietin or IL-7. ILC2 activities are negatively regulated by interferons; however, lack of type I and III interferon synthesis in asthmatic airways exacerbates inflammation during respiratory viral infection.

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Acknowledgments

This research was supported by the Japan Agency for Medical Research and Development (AMED) under grant number JP18ek0410026.

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Authors and Affiliations

  1. Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan

    Koichiro Asano

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  1. Koichiro Asano
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Correspondence to Koichiro Asano .

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Editors and Affiliations

  1. Department of Hematology and Respiratory Medicine, Kochi Medical School, Nankoku-shi, Kochi, Japan

    Akihito Yokoyama

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Asano, K. (2019). Group 2 Innate Lymphoid Cells and Asthma. In: Yokoyama, A. (eds) Advances in Asthma. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-13-2790-2_2

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  • DOI: https://doi.org/10.1007/978-981-13-2790-2_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2789-6

  • Online ISBN: 978-981-13-2790-2

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