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Chemiexcitation of Melanin and Melanoma Pathogenesis

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Skin Aging & Cancer

Abstract

Solar radiation is an ultimate source of energy for the existence of life on earth. The UV radiation is a part of solar radiation that acts as a carcinogenic agent by the formation of cyclobutane pyrimidine dimers (CPDs). Earlier studies documented the mechanism of CPD formation in the presence of UV light instantly but recent studies showed the damage of DNA is continuing even after the exposure of UV light till hours. The mechanism of this delayed or dark CPD resembles with chemiluminescence process. The study further detailed the key role of melanocytes in this process of dark CPD formation by chemiexcitation of melanin pigment. Melanin gets excited to higher energy level after UV exposure by the production of free radicals like nitric oxide and superoxide. Thus, this excitation of melanin pigments is responsible factor for damage of DNA after exposure of longer wavelength of UVA which ultimately promotes melanoma pathogenesis.

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Author information

Authors and Affiliations

  1. Department of Forensics Science, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India

    Saroj Kumar Amar

  2. Department of Pharmaceutical Engineering & Technology, IIT-BHU, Varanasi, Uttar Pradesh, India

    Dhanananajay Kumar

Authors
  1. Saroj Kumar Amar
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  2. Dhanananajay Kumar
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Editor information

Editors and Affiliations

  1. Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Ashish Dwivedi

  2. Department of Medicine, Division of Hematology/Oncology, Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Neeraj Agarwal

  3. Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

    Lipika Ray

  4. School of Biomedical Engineering, Indian Institute of Technology BHU, Varanasi, Uttar Pradesh, India

    Amit Kumar Tripathi

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Amar, S.K., Kumar, D. (2019). Chemiexcitation of Melanin and Melanoma Pathogenesis. In: Dwivedi, A., Agarwal, N., Ray, L., Tripathi, A. (eds) Skin Aging & Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-13-2541-0_8

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