Abstract
Optic disc melanocytoma is a unique variant of melanocytic nevus, first named by Zimmerman and Garron in 1962 (Int Ophthalmol Clin. 2:431–440), which sometimes contiguously involves adjacent choroid and retina. Optic disc melanocytoma is believed to be a congenital and non-hereditary lesion that does not show racial predilection such as uveal melanoma. Historically melanocytoma was confused with uveal melanoma both clinically and histopathologically. The diagnosis of melanocytoma is usually given by ophthalmoscopic findings because of characteristic pigment mass on the optic disc. Ancillary examinations include ultrasonography, fluorescein and indocyanine green angiography, fundus autofluorescence, optical coherent tomography (OCT), and OCT angiography. Histopathologically melanocytoma is a deeply pigmented benign tumor composed of round to oval nevus cells primarily arising on the optic disc. It is generally considered as stationary lesion but can grow slowly and progressively affect visual field and visual acuity. In rare instances, it can get spontaneous necrosis or transform into melanoma that often cause severe visual loss.
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Furuta, M. (2019). Optic Disc Melanocytoma. In: Rojanaporn, D. (eds) Ocular Oncology. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-13-2336-2_14
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