Skip to main content
SpringerLink
Log in

Cell Death or Survival Against Oxidative Stress

  • Chapter
  • First Online:
Proteomics of Peroxisomes

Part of the book series: Subcellular Biochemistry ((SCBI,volume 89))

Abstract

Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M (2014) PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein. Trafffic 15:94–103

    Article  CAS  Google Scholar 

  • Borgese N, Brambillasca S, Colombo S (2007) How tails guide tail-anchored proteins to their destinations. Curr Opin Cell Biol 19:368–375

    Article  CAS  Google Scholar 

  • Carvalho AF, Pinto MP, Grou CP, Alencastre IS, Fransen M, Sá-Miranda C, Azevedo JE (2007) Ubiquitination of mammalian Pex5p, the peroxisomal import receptor. J Biol Chem 282:31267–31272

    Article  CAS  Google Scholar 

  • Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Chung-Ping Liao C-P, Gavathiotis E, Hsieh JJ, Cheng EH (2015) An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nat Cell Biol 17:1270–1281

    Article  CAS  Google Scholar 

  • Cheng EH-YA, Wei MC, Weiler S, Flavell RA, Mak TM, Lindsten T, Korsmeyer SJ (2001) BCL-2, BCL-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8:705–711

    Article  CAS  Google Scholar 

  • Cheng EH-Y, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (2003) VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science 301:513–517 (New York, N.Y)

    Article  CAS  Google Scholar 

  • Costello JL, Castro IG, Camões F, Schrader TA, McNeall D, Yang J, Giannopoulou E-A, Gomes S, Pogenberg V, Bonekamp NA, Ribeiro D, Wilmanns M, Jedd G, Islinger M, Schrader M (2017) Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. J Cell Sci 130:1675–1687

    Article  CAS  Google Scholar 

  • Czabotar PE, Lessene G, Strasser A, Adams JM (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 15:49–63

    Article  CAS  Google Scholar 

  • Dammai V, Subramani S (2001) The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell 105:187–196

    Article  CAS  Google Scholar 

  • Delille HK, Schrader M (2008) Targeting of hFis1 to peroxisomes is mediated by Pex19p. J Biol Chem 283:31107–31115

    Article  CAS  Google Scholar 

  • Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141:668–681

    Article  CAS  Google Scholar 

  • Eriksson AM, Zetterqvist M-A, Lundgren B, Andersson K, Beije B, DePierre JW (1991) Studies on the intracellular distributions of soluble epoxide hydrolase and of catalase by digitonin-permeabilization of hepatocytes isolated from control and clofibrate-treated mice. Eur J Biochem 198:471–476

    Article  CAS  Google Scholar 

  • Eriksson AM, Lundgren B, Andersson K, DePierre JW (1992) Is the cytosolic catalase induced by peroxisome proliferators in mouse liver on its way to the peroxisomes? FEBS Lett 308:211–214

    Article  CAS  Google Scholar 

  • Fujiki Y, Miyata N, Mukai S, Okumoto K, Cheng EH (2017) BAK regulates catalase release from peroxisomes. Mol Cell Oncol 4 (article: e1306610)

    Article  Google Scholar 

  • Ghaedi K, Itagaki A, Toyama R, Tamura S, Matsumura T, Kawai A, Shimozawa N, Suzuki Y, Kondo N, Fujiki Y (1999) Newly identified Chinese hamster ovary cell mutants defective in peroxisome assembly represent complementation group A of human peroxisome biogenesis disorders and one novel group in mammals. Exp Cell Res 248:482–488

    Article  CAS  Google Scholar 

  • Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodríguez-Borges JE, Sá-Miranda C, Fransen M, Azevedo JE (2012) Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate. J Biol Chem 287:12815–12827

    Article  CAS  Google Scholar 

  • Hartman P, Belmont P, Zuber S, Ishii N, Anderson J (2003) Relationship between catalase and life span in recombinant inbred strains of Caenorhabditis elegans. J Nematol 35:314–319

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hegde RS, Keenan RJ (2011) Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat Rev Mol Cell Biol 12:787–798

    Article  CAS  Google Scholar 

  • Hosoi K, Miyata N, Mukai S, Furuki S, Okumoto K, Cheng EH, Fujiki Y (2017) The VDAC2–BAK axis regulates peroxisomal membrane permeability. J Cell Biol 216:709–721

    Article  CAS  Google Scholar 

  • Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS (2016) Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation. Mol Cell 63:21–33

    Article  CAS  Google Scholar 

  • Itoyama A, Michiyuki S, Honsho M, Yamamoto T, Moser A, Yoshida Y, Fujiki Y (2013) Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol Open 2:998–1006

    Article  CAS  Google Scholar 

  • Kim H, Rafiuddin-Shah M, Tu H-C, Jeffers JR, Zambetti GP, Hsieh JJ-D, Cheng EH-Y (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8:1348–1358

    Article  CAS  Google Scholar 

  • Kobayashi S, Tanaka A, Fujiki Y (2007) Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. Exp Cell Res 313:1675–1686

    Article  CAS  Google Scholar 

  • Kutay U, Hartmann E, Rapoport TA (1993) A class of membrane proteins with a C-terminal anchor. Trends Cell Biol 3:72–75

    Article  CAS  Google Scholar 

  • Miyata N, Fujiki Y (2005) Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export. Mol Cell Biol 25:10822–10832

    Article  CAS  Google Scholar 

  • Newmeyer DD, Ferguson-Miller S (2003) Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112:481–490

    Article  CAS  Google Scholar 

  • O’Neill KL, Huang K, Zhang J, Chen Y, Luo X (2016) Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane. Genes Dev 30:973–988

    Article  Google Scholar 

  • Okumoto K, Misono S, Miyata N, Matsumoto Y, Mukai S, Fujiki Y (2011) Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling. Traffic 12:1067–1083

    Article  CAS  Google Scholar 

  • Otera H, Fujiki Y (2012) Pex5p imports folded tetrameric catalase by interaction with Pex13p. Trafffic 13:1364–1377

    Article  CAS  Google Scholar 

  • Platta HW, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R (2005) Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol 7:817–822

    Article  CAS  Google Scholar 

  • Platta HW, El Magraoui F, Schlee D, Grunau S, Girzalsky W, Erdmann R (2007) Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. J Cell Biol 177:197–204

    Article  CAS  Google Scholar 

  • Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS (2008) The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell 134:634–645

    Article  CAS  Google Scholar 

  • Setoguchi K, Otera H, Mihara K (2006) Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins. EMBO J 25:5635–5647

    Article  CAS  Google Scholar 

  • Tait SWG, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621–632

    Article  CAS  Google Scholar 

  • Tateishi K, Okumoto K, Shimozawa N, Tsukamoto T, Osumi T, Suzuki Y, Kondo N, Okano I, Fujiki Y (1997) Newly identified Chinese hamster ovary cell mutants defective in peroxisome biogenesis represent two novel complementation groups in mammals. Eur J Cell Biol 73:352–359

    CAS  PubMed  Google Scholar 

  • Titorenko VI, Terlecky SR (2011) Peroxisome metabolism and cellular aging. Traffic 12:252–259

    Article  CAS  Google Scholar 

  • Walton PA, Brees C, Lismont C, Apanasets O, Fransen M (2017) The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress. Biochem Biophys Acta 1864:1833–1843

    Article  CAS  Google Scholar 

  • Wanders RJA, Waterham HR (2006) Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem 75:295–332

    Article  CAS  Google Scholar 

  • Wang X (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15:2922–2933

    CAS  PubMed  Google Scholar 

  • Wei MC, Zong W-X, Cheng EH-Y, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727–730 (New York, N.Y)

    Article  CAS  Google Scholar 

  • Yagita Y, Hiromasa T, Fujiki Y (2013) Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. J Cell Biol 200:651–666

    Article  CAS  Google Scholar 

  • Yagita Y, Shinohara K, Abe Y, Nakagawa K, Al-Owain M, Alkuraya FS, Fujiki Y (2017) Deficiency of a retinal dystrophy protein, acyl-CoA binding domain-containing 5 (ACBD5), impairs peroxisomal β-oxidation of very-long-chain fatty acids. J Biol Chem 292:691–705

    Article  CAS  Google Scholar 

  • Yano T, Oku M, Akeyama N, Itoyama A, Yurimoto H, Kuge S, Fujiki Y, Sakai Y (2010) A novel fluorescent sensor protein for visualization of redox states in the cytoplasm and in peroxisomes. Mol Cell Biol 30:3758–3766

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the supports: MEXT KAKENHI grant JP26116007 and JSPS KAKENHI grants JP24247038, JP25112518, JP25116717, JP15K14511, JP15K21743, JP17H03675, and grants from the Takeda Science Foundation, the Naito Foundation, the Japan, Foundation for Applied Enzymology, and the Novartis Foundation (Japan) for the Promotion of Science.

Author information

Author notes

  1. Non Miyata

    Present address: Department of Chemistry, Faculty of Sciences, Kyushu University, 819-0395, Nishi-ku, Fukuoka, Japan

Authors and Affiliations

  1. Department of Biology, Faculty of Sciences, Kyushu University, 819-0395, Nishi-ku, Fukuoka, Japan

    Non Miyata & Kanji Okumoto

  2. Graduate School of Systems Life Sciences, Kyushu University, 819-0395, Nishi-ku, Fukuoka, Japan

    Kanji Okumoto

  3. Medical Institute of Bioregulation, Kyushu University, 812-8582, Higashi-ku, Fukuoka, Japan

    Yukio Fujiki

Authors
  1. Non Miyata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kanji Okumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukio Fujiki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yukio Fujiki .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC, Granada, Spain

    Luis A. del Río

  2. Department of Biosciences, University of Exeter, Exeter, UK

    Michael Schrader

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Miyata, N., Okumoto, K., Fujiki, Y. (2018). Cell Death or Survival Against Oxidative Stress. In: del Río, L., Schrader, M. (eds) Proteomics of Peroxisomes. Subcellular Biochemistry, vol 89. Springer, Singapore. https://doi.org/10.1007/978-981-13-2233-4_20

Download citation

Publish with us

Policies and ethics

Search

Navigation