Abstract
Single types of methodologies are no longer sufficient to adequately describe complex biological structures. As a result, integrated approaches that combine complementary data are being developed. This chapter describes the integration of nuclear magnetic resonance and small-angle scattering approaches to characterize solution structures of multi-domain proteins.
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Acknowledgment
I thank all former and present members of Gronenborn laboratory for their contributions to our studies referenced here and Teresa Brosenitsch for excellent editorial help. This work was supported by a National Institutes of Health Grant RO1GM080642 (A.M.G.).
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Gronenborn, A.M. (2018). Harnessing the Combined Power of SAXS and NMR. In: Nakamura, H., Kleywegt, G., Burley, S., Markley, J. (eds) Integrative Structural Biology with Hybrid Methods. Advances in Experimental Medicine and Biology, vol 1105. Springer, Singapore. https://doi.org/10.1007/978-981-13-2200-6_11
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