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Neurodevelopmental Disorders in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study)

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Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease

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Abstract

Neurodevelopmental disorders are a collective term that encompasses neuropsychiatric conditions whose manifestations occurs very early in life. Among these, attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are the two most common and prevalent disorders. In clinical reality, however, no single sign or symptom that is solely associated with a later diagnosis of ADHD or ASD; early trajectories that lead to ADHD or ASD remains to be investigated. In addition, growing number of studies have reported environmental risk factors for ADHD and ASD, which may account for unexplained aetiology of these disorders. To this point, researchers in this field have been keen to elucidate early trajectories and environmental risk factors for ADHD and ASD using birth cohorts based on general population. The authors established the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) in 2007. A total of 1258 neonates from 1138 mothers were included and are planned to be followed up for 8 years. The HBC Study team found that five, neurodevelopmental trajectories during the first two years were extracted; three out of five trajectory classes were associated with an increased risk for having a diagnosis of ASD. The HBC Study will provide a unique and valuable resource for providing new insights into neurodevelopmental disorders.

The HBC Study team, including past members, are (in an alphabetical order): Ms. Sanae Aoyagi, Rie Gonda, Emi Hatano, Emi Higashimoto, Maiko Honda, Tomoyo Isobe, Noriko Kodera, Yumeno Kugizaki, Hiroko Muraki, Atsuko Nakamura, Chikako Nakayasu, Makiko Narumiya, Yuko Nishimura, Michiyo Nishizawa, Yuko Osuka, Eriko Sato, Haruka Suzuki, Yukiko Suzuki, Riyo Takabayashi, Mana Yamashita, Mr. Ryuji Nakahara, Kei Shigeno, Drs. Ryosuke Asano, Damee Choi, Yusaku Endoh, Taeko Harada, Koichi Hirano, Takanobu Horikoshi, Thanseem Ismail, Hiroaki Itoh, Toshiki Iwabuchi, Keiko Iwata, Yasuhide Iwata, Yosuke Kameno, Naohiro Kanayama, Emiko Kawai, Masayoshi Kawai, Daisuke Kurita, Yujin K. Kuroda, Hitoshi Kuwabara, Kaori Matsumoto, Taishi Miyachi, Hideo Matsuzaki, Norio Mori, Tsuruko Mori, Kyoko Nakaizumi, Kazuhiko Nakamura, Tomoko Nishimura, Yoko Nomura, Ryuichiro Ohshima, Akemi Okumura, Anitha A. Pillai, Yoko Sagawa, Chie Shimmura, Yui Seno, Shiro Suda, Genichi Sugihara, Katsuaki Suzuki, Teruhiko Suzuki, Kiyokazu Takebayashi, Nori Takei, Masatsugu Tsujii, Satoshi Uchiyama, Mahesh Mundalil Vasu, Tomoyasu Wakuda, Keisuke Wakusawa, Manabu Wakuta, Kohei Yamada, Hidenori Yamasue and Masamichi Yokokura.

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Abbreviations

ADHD:

Attention-deficit hyperactivity disorder

ADHD-RS:

ADHD Rating Scale

ADOS:

Autism Diagnostic Observation Schedule

ASD:

Autism spectrum disorder

CI:

Confidence interval

DSM-5:

Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition

DSM-IV:

Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition

HBC Study:

Hamamatsu Birth Cohort for Mothers and Children

ICD-10:

International Classification of Mental and Behavioural Disorders, Tenth Edition

M-CHAT:

Modified Checklist for Autism in Toddlers

MSEL:

Mullen Scales of Early Learning

PFOS:

Perfluorooctane sulfonate

POPs:

Persistent organic pollutants

SD:

Standard deviation

SDQ:

Strength and Difficulties Questionnaire

WISC-IV:

Wechsler Intelligence Scale for Children, Fourth edition

WPPSI:

Wechsler Preschool and Primary Scale of Intelligence

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Acknowledgements

The authors thank Dr. Tetsuo Kato of the Kato Maternity Clinic for enrolling study participants. The authors are grateful to Drs. K. Sugihara, M. Sugimura, K. Takeuchi, K. Suzuki, Y. Murakami, Y. Koumura, Y. Miyabe, K. Hirai, Y. Nakamura, R. Koizumi, H. Murakami, Y. Kobayashi-Koumura, and K. Muramatsu-Kato and to all attending obstetricians for enrolling pregnant women to participate in the study. The authors thank the chief midwife, Ms. Kiyomi Hinoki, and all the midwives and staff at the Hamamatsu University School of Medicine maternity clinic, for enrolling participants.

Funding: This work is supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (K.J. Tsuchiya, S. Takagai) and the SENSHIN Medical Research Foundation (K.J. Tsuchiya).

Conflict of Interest: None declared.

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Authors and Affiliations

  1. Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Kenji J. Tsuchiya

  2. United Graduate School of Child Development, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Kenji J. Tsuchiya & Shu Takagai

  3. Department of Child and Adolescent Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Shu Takagai

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  1. Kenji J. Tsuchiya
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Correspondence to Kenji J. Tsuchiya .

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Editors and Affiliations

  1. Chuo University Health Center, Tokyo, Japan

    Fumihiro Sata

  2. Waseda University, Tokyo, Japan

    Hideoki Fukuoka

  3. University of Southampton, Academic Unit of Human Development & Health, Southampton, UK

    Mark Hanson

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Tsuchiya, K.J., Takagai, S. (2019). Neurodevelopmental Disorders in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study). In: Sata, F., Fukuoka, H., Hanson, M. (eds) Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-2194-8_11

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