Abstract
Neurosurgical procedures require flawless hemostasis, as even a small bleeding can produce a significant damage, not only impairing a good outcome but causing life-threatening events. Patients requiring general anesthesia for neurosurgical procedures can be affected by inherited or acquired coagulation disorders. While the first are rarer conditions, the latter are becoming more frequent given the increased number of patients receiving anticoagulants and/or antiplatelet medications. Identification of individual patients with preexisting hemostatic defects and an adequate intraoperative monitoring remain crucial to prevent otherwise unexpected bleeding complications, to manage existing bleeding adequately, and to avoid unnecessary patient exposure to blood products.
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References
Steinberg B, Piccini J. Anticoagulation in atrial fibrillation. Br Med J. 2014;348:g2116.
North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–53.
Adeeb N, Griessenauer CJ, Foreman PM, et al. Use of platelet function testing before pipeline embolization device placement: a multicenter cohort study. Stroke. 2017;48:1322–30.
Thompson BB, Béjot Y, Caso V, et al. Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review. Neurology. 2010;75:1333–42.
Pallister CJ, Watson MS. Haematology. Scion Publishing; 2010. p. 334–6.
Hoffbrand AV. Essential haematology. Oxford: Blackwell Science; 2002. p. 241–3.
Fijnvandraat K, Cnossen MH, Leebeek FWG, et al. Diagnosis and management of haemophilia. Br Med J. 2012;344:e2707.
Khan S, Dickerman JD. Hereditary thrombophilia. Thromb J. 2006;4:15.
Summary of Product Characteristics: Warfarin, Taro Pharmaceuticals UK Ltd, May 2013. www.medicines.org.uk. Accessed 7 Jan 2016.
Summary of Product Characteristics: Xarelto, Bayer Plc. 2015. www.medicines.org.uk. Accessed 7 Jan 2016.
Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with AF. N Engl J Med. 2009;361:1139–51.
Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2010;377:431–41.
Wallenten L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045–57.
Hegde A, Nair R, Upadhyaya S. Spontaneous intracerebral hemorrhage in hemophiliacs—a treatment dilemma. Int J Surg Case Rep. 2016;29:17–9.
Fawole A, Hamed D, Crowther M. Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban. Cleve Clin J Med. 2013;80:443–51.
Yu PJ, Cassiere HA, Dellis SL, et al. P2Y12 platelet function assay for assessment of bleeding risk in coronary artery bypass grafting. J Card Surg. 2014;29:312–6.
Nordeen JD, Patel AV, Darracott RM, et al. Clopidogrel resistance by P2Y12 platelet function testing in patients undergoing neuroendovascular procedures. J Vasc Interv Neurol. 2013;6:26–34.
Bolliger D, Seeberger MD, Tanaka KA. Principles and practice of thromboelastography in clinical coagulation management and transfusion practice. Transfus Med Rev. 2012;26:1–13.
Liumbruno GM, Bennardello F, Lattanzio A, et al. Recommendations for the transfusion management of patients in the peri-operative period. I. The pre-operative period. Blood Transfus. 2011;9:19–40.
Stiene-Martin EA, Lotspeich-Steininger CA, Koepke JA. Clinical hematology. Principles, procedures, correlations. 2nd ed. Philadelphia: Lippincott; 1998. p. 599–611.
Soghomonyan S, Stoicea N, Sandhu GS. The role of permissive and induced hypotension in current neuroanesthesia practice. Front Surg. 2017;4:1.
Frykholm P, Pikwer A, Hammarskjöld F, et al. Clinical guidelines on central venous catheterization. Acta Anaesthesiol Scand. 2014;58:508–24.
Makris M, Van Veen JJ. Three or four factor prothrombin complex concentrate for emergency anticoagulation reversal? Blood Transfus. 2011;9:117–9.
Baglin TP, Keeling DM, Watson HG. Guidelines on oral anticoagulation (warfarin): third edition—2005 update. Br J Haematol. 2006;132:277–85.
Lin Y, Foltz LM. Proposed guidelines for platelet transfusion. BCMJ. 2005;47(5):245–8.
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Lamperti, M., Khozhenko, A., Tufegdzic, B. (2019). Neuroanesthesia and Coexisting Coagulation Problems. In: Prabhakar, H., Singhal, V., Gupta, N. (eds) Co-existing Diseases and Neuroanesthesia. Springer, Singapore. https://doi.org/10.1007/978-981-13-2086-6_10
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DOI: https://doi.org/10.1007/978-981-13-2086-6_10
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