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Advances in Pain Research: Mechanisms and Modulation of Chronic Pain pp 179–199Cite as

Neuroimaging Studies of Primary Dysmenorrhea

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1099))

Abstract

Primary dysmenorrhea (PDM), cyclic menstrual pain in the absence of pelvic anomalies, is one of the most common gynecological disorders in reproductive females. Classified as chronic pelvic pain syndrome, PDM encompasses recurrent spontaneous painful (“on”) and pain-free (“off”) states and is thus a good clinical model to study state- and trait-related changes of pain in the brain. In this chapter, we summarize state-of-the-art neuroimaging studies of primary dysmenorrhea from phenotype and endophenotype to genotype facets. Structural and functional brain alterations associated with primary dysmenorrhea are discussed.

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Acknowledgments

These studies and our laboratories were financially supported by the Ministry of Science Technology, Ministry of Education, National Yang-Ming University, Taipei Veterans General Hospital, and the Joint research program between Taipei Veterans General Hospital and National Taiwan University Hospital. We thank Dr. Hsiang-Tai Chao for performing the clinical assessment and Dr. Ming-Wei Lin for performing the genotyping of these studies. All participants are thanked for their support and contribution to these studies.

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Authors and Affiliations

  1. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan

    Intan Low, Shyh-Yuh Wei, Wei-Chi Li, Lin-Chien Lee, Jen-Chuen Hsieh & Li-Fen Chen

  2. Integrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan

    Intan Low, Jen-Chuen Hsieh & Li-Fen Chen

  3. Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan

    Pin-Shiuan Lee & Li-Fen Chen

  4. Brain Research Center, National Yang-Ming University, Taipei, Taiwan

    Jen-Chuen Hsieh & Li-Fen Chen

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Correspondence to Jen-Chuen Hsieh .

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  1. Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

    Bai-Chuang Shyu

  2. Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), Okazaki, Aichi, Japan

    Makoto Tominaga

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Low, I. et al. (2018). Neuroimaging Studies of Primary Dysmenorrhea. In: Shyu, BC., Tominaga, M. (eds) Advances in Pain Research: Mechanisms and Modulation of Chronic Pain. Advances in Experimental Medicine and Biology, vol 1099. Springer, Singapore. https://doi.org/10.1007/978-981-13-1756-9_16

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