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Molecular Basis and Emerging Strategies for Anti-aging Interventions pp 83–96Cite as

Novel Classification Perspective of Geroprotective and Senolytic Drugs as an Antiaging Strategy

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Abstract

Aging is an inevitable, physiologically irreversible, and progressive process. It involves various detrimental changes in the ability to maintain cellular homeostasis. During the aging period, senescent cells are accumulated. Due to the significant medical advances in the treatment of various life-threatening diseases, life expectancy is rising day by day. Thus, higher speed of population aging brings enhanced prevalence of age-related disorders. Increasing mid-life quality and extending the life span of aging individuals seem possible by decreasing the rate of aging process with the help of various pharmacologically active substances called as geroprotective or senolytic drugs. Several numbers of naturally found and synthetic substances may provide a source of therapeutic drugs which are proposed to have some geroprotective or senolytic effects, reducing the rate of aging and extending the life span. These therapeutic drugs have some beneficial effects on cellular metabolism such as antioxidant, free radical scavenger, immunomodulator, and metal chelator activities. Some of the aforementioned drugs are called as smart molecules because of their pluripotency effects. Attributed to their properties, these drugs may overcome impaired cellular metabolic homeostasis. This chapter aimed to classify geroprotective and senolytic drugs via their structural properties and pharmacological mechanisms.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, University of Istanbul, Istanbul, Turkey

    Karolin Yanar

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  1. Karolin Yanar
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Editors and Affiliations

  1. Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh, India

    Syed Ibrahim Rizvi

  2. Medical Biochemistry, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Ufuk Çakatay

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Yanar, K. (2018). Novel Classification Perspective of Geroprotective and Senolytic Drugs as an Antiaging Strategy. In: Rizvi, S., Çakatay, U. (eds) Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-13-1699-9_6

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