Skip to main content
SpringerLink
Log in

Sentinel Node Navigation Surgery for Endometrial Cancer

  • Chapter
  • First Online:
Surgery for Gynecologic Cancer

Part of the book series: Comprehensive Gynecology and Obstetrics ((CGO))

  • 680 Accesses

Abstract

To date, the results of the clinical trial of sentinel node navigation surgery (SNNS) for endometrial cancer are not reported, and SNNS should be not yet performed as a clinical practice. SNNS is thought to be performed as a clinical trial in the institutions with enough experiences of SN mapping. Regarding the methods of the tracer injection and tracer detection, the diagnostic accuracy of metastasis, the clinical significance of ITC, or micrometastasis, the oncologic significance of solitary metastasis-positive sentinel lymph node (SN) in para-aortic basin, the usefulness of SN biopsy using surgical robots with fluorescence imaging system for detecting ICG, accumulations of clinical trials, and the data analysis in many facilities are needed so that SNNS comes to be safely performed as a clinical practice. Furthermore, the standardization of the diagnosing method for the pathological search for SN and the establishment of the molecular biologic laboratory procedure are necessary, too. However, we think SNNS will emerge as a promising, elegant solution to the ongoing discussion regarding lymphadenectomy in the initial surgical management of endometrial cancer in order to prevent many patients from receiving oversurgery, in order to properly select patients who need to receive lymphadenectomy, and in order to definitely evaluate the risk of recurrence by using ultra-staging or biological diagnosing method in the near future.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, et al. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol. 2008;26(6):884–9. https://doi.org/10.1200/JCO.2007.14.0566.

    Article  PubMed  Google Scholar 

  2. Altgassen C, Hertel H, Brandstädt A, Köhler C, Dürst M, Schneider A, AGO Study Group. Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO Study Group. J Clin Oncol. 2008;26(18):2943–51. https://doi.org/10.1200/JCO.2007.13.8933.

    Article  PubMed  Google Scholar 

  3. Burke TW, Levenback C, Tornos C, Morris M, Wharton JT, Gershenson DM. Intraabdominal lymphatic mapping to direct selective pelvic and paraaortic lymphadenectomy in women with high-risk endometrial cancer: results of a pilot study. Gynecol Oncol. 1996;62(2):169–73.

    Article  CAS  Google Scholar 

  4. Ballester M, Dubernard G, Lécuru F, Heitz D, Mathevet P, Marret H, et al. Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO). Lancet Oncol. 2011;12(5):469–76. https://doi.org/10.1016/S1470-2045(11)70070-5.

    Article  PubMed  Google Scholar 

  5. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Uterine Neoplasms. Version 1.2018—October 13, 2017. NCCN.org. https://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf. Accessed 25 Feb 2018.

  6. Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J, et al.; ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up. Int J Gynecol Cancer. 2016;26(1):2–30. https://doi.org/10.1097/IGC.0000000000000609.

    Article  PubMed  Google Scholar 

  7. Holloway RW, Abu-Rustum NR, Backes FJ, Boggess JF, Gotlieb WH, Jeffrey Lowery W, et al. Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations. Gynecol Oncol. 2017;146(2):405–15. https://doi.org/10.1016/j.ygyno.2017.05.027.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Soliman PT, Westin SN, Dioun S, Sun CC, Euscher E, Munsell MF, et al. A prospective validation study of sentinel lymph node mapping for high-risk endometrial cancer. Gynecol Oncol. 2017;146(2):234–9. https://doi.org/10.1016/j.ygyno.2017.05.016.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Schiavone MB, Zivanovic O, Zhou Q, Leitao MM Jr, Levine DA, Soslow RA, et al. Survival of patients with uterine carcinosarcoma undergoing sentinel lymph node mapping. Ann Surg Oncol. 2016;23(1):196–202. https://doi.org/10.1245/s10434-015-4612-2.

    Article  PubMed  Google Scholar 

  10. Antonsen SL, Jensen LN, Loft A, Berthelsen AK, Costa J, Tabor A, et al. MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer—a multicenter prospective comparative study. Gynecol Oncol. 2013;128(2):300–8. https://doi.org/10.1016/j.ygyno.2012.11.025.

    Article  CAS  PubMed  Google Scholar 

  11. Chang MC, Chen JH, Liang JA, Yang KT, Cheng KY, Kao CH. 18F-FDG PET or PET/CT for detection of metastatic lymph nodes in patients with endometrial cancer: a systematic review and meta-analysis. Eur J Radiol. 2012;81(11):3511–7. https://doi.org/10.1016/j.ejrad.2012.01.024.

    Article  PubMed  Google Scholar 

  12. Nogami Y, Banno K, Irie H, Iida M, Kisu I, Masugi Y, et al. The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer: clinical and pathological factors influencing it. Jpn J Clin Oncol. 2015;45(1):26–34. https://doi.org/10.1093/jjco/hyu161.

    Article  PubMed  Google Scholar 

  13. Kitajima K, Murakami K, Yamasaki E, Fukasawa I, Inaba N, Kaji Y, et al. Accuracy of 18F-FDG PET/CT in detecting pelvic and paraaortic lymph node metastasis in patients with endometrial cancer. AJR Am J Roentgenol. 2008;190(6):1652–8. https://doi.org/10.2214/AJR.07.3372.

    Article  PubMed  Google Scholar 

  14. Ansari M, Rad MA, Hassanzadeh M, Gholami H, Yousefi Z, Dabbagh VR, et al. Sentinel node biopsy in endometrial cancer: systematic review and meta-analysis of the literature. Eur J Gynaecol Oncol. 2013;34(5):387–401.

    CAS  PubMed  Google Scholar 

  15. Ruscito I, Gasparri ML, Braicu EI, Bellati F, Raio L, Sehouli J, et al. Sentinel node mapping in cervical and endometrial cancer: indocyanine green versus other conventional dyes-a meta-analysis. Ann Surg Oncol. 2016;23(11):3749–56. https://doi.org/10.1245/s10434-016-5236-x.

    Article  PubMed  Google Scholar 

  16. Delpech Y, Coutant C, Darai E, Barranger E. Sentinel lymph node evaluation in endometrial cancer and the importance of micrometastases. Surg Oncol. 2008;17:237–45. https://doi.org/10.1016/j.suronc.2008.04.001.

    Article  PubMed  Google Scholar 

  17. Kataoka F, Susumu N, Yamagami W, Kuwahata M, Takigawa A, Nomura H, et al. The importance of para-aortic lymph nodes in sentinel lymph node mapping for endometrial cancer by using hysteroscopic radio-isotope tracer injection combined with subserosal dye injection: Prospective study. Gynecol Oncol. 2016;140(3):400–4. https://doi.org/10.1016/j.ygyno.2015.12.023.

    Article  PubMed  Google Scholar 

  18. Niikura H, Okamura C, Utsunomiya H, Yoshinaga K, Akahira J, Ito K, et al. Sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol. 2004;92:669–74.

    Article  Google Scholar 

  19. Niikura H, Kaiho-Sakuma M, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, et al. Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol. 2013;131(2):299–303. https://doi.org/10.1016/j.ygyno.2013.08.018.

    Article  PubMed  Google Scholar 

  20. Yamagami W, Susumu N, Kataoka F, Makabe T, Sakai K, Ninomiya T, et al. A comparison of dye versus fluorescence methods for sentinel lymph node mapping in endometrial cancer. Int J Gynecol Cancer. 2017;27(7):1517–24. https://doi.org/10.1097/IGC.0000000000000997.

    Article  PubMed  Google Scholar 

  21. Tanaka T, Terai Y, Fujiwara S, Tanaka Y, Sasaki H, Tsunetoh S, et al. The detection of sentinel lymph nodes in laparoscopic surgery can eliminate systemic lymphadenectomy for patients with early stage endometrial cancer. Int J Clin Oncol. 2018;23(2):305–13. https://doi.org/10.1007/s10147-017-1196-9.

    Article  PubMed  Google Scholar 

  22. Cormier B, Rozenholc AT, Gotlieb W, Plante M, Giede C, Communities of Practice (CoP) Group of Society of Gynecologic Oncology of Canada (GOC). Sentinel lymph node procedure in endometrial cancer: A systematic review and proposal for standardization of future research. Gynecol Oncol. 2015;138(2):478–85. https://doi.org/10.1016/j.ygyno.2015.05.039.

    Article  PubMed  Google Scholar 

  23. Bodurtha Smith AJ, Fader AN, Tanner EJ. Sentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;216(5):459–476.e10. https://doi.org/10.1016/j.ajog.2016.11.1033.

    Article  PubMed  Google Scholar 

  24. Khoury-Collado F, Glaser GE, Zivanovic O, Sonoda Y, Levine DA, Chi DS, et al. Improving sentinel lymph node detection rates in endometrial cancer: how many cases are needed? Gynecol Oncol. 2009;115(3):453–5. https://doi.org/10.1016/j.ygyno.2009.08.026.

    Article  PubMed  Google Scholar 

  25. Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, et al. A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study. Lancet Oncol. 2017;18(3):384–92. https://doi.org/10.1016/S1470-2045(17)30068-2.

    Article  PubMed  Google Scholar 

  26. Niikura H, Okamoto S, Yoshinaga K, Nagase S, Takano T, Ito K, et al. Detection of micrometastases in the sentinel lymph nodes of patients with endometrial cancer. Gynecol Oncol. 2007;105(3):683–6.

    Article  Google Scholar 

  27. Holloway RW, Gupta S, Stavitzski NM, Zhu X, Takimoto EL, Gubbi A, et al. Sentinel lymph node mapping with staging lymphadenectomy for patients with endometrial cancer increases the detection of metastasis. Gynecol Oncol. 2016;141(2):206–10. https://doi.org/10.1016/j.ygyno.2016.02.018.

    Article  PubMed  Google Scholar 

  28. Kim CH, Soslow RA, Park KJ, Barber EL, Khoury-Collado F, Barlin JN, et al. Pathologic ultrastaging improves micrometastasis detection in sentinel lymph nodes during endometrial cancer staging. Int J Gynecol Cancer. 2013;23:964–70.

    Article  Google Scholar 

  29. Nagai T, Niikura H, Okamoto S, Nakabayashi K, Matoda M, Utsunomiya H, et al. A new diagnostic method for rapid detection of lymph node metastases using a one-step nucleic acid amplification (OSNA) assay in endometrial cancer. Ann Surg Oncol. 2015;22(3):980–6. https://doi.org/10.1245/s10434-014-4038-2.

    Article  PubMed  Google Scholar 

  30. López-Ruiz ME, Diestro MD, Yébenes L, Berjón A, Díaz de la Noval B, Mendiola M, et al. One-step nucleic acid amplification (OSNA) for the detection of sentinel lymph node metastasis in endometrial cancer. Gynecol Oncol. 2016;143(1):54–9. https://doi.org/10.1016/j.ygyno.2016.07.106.

    Article  CAS  PubMed  Google Scholar 

  31. Barlin JN, Khoury-Collado F, Kim CH, Leitao MM Jr, Chi DS, Sonoda Y, et al. The importance of applying a sentinel lymph node mapping algorithm in endometrial cancer staging: beyond removal of blue nodes. Gynecol Oncol. 2012;125(3):531–5. https://doi.org/10.1016/j.ygyno.2012.02.021.

    Article  PubMed  Google Scholar 

  32. Geppert B, Lönnerfors C, Bollino M, Persson J. Sentinel lymph node biopsy in endometrial cancer-Feasibility, safety and lymphatic complications. Gynecol Oncol. 2018;148(3):491–8. https://doi.org/10.1016/j.ygyno.2017.12.017.

    Article  PubMed  Google Scholar 

  33. St Clair CM, Eriksson AG, Ducie JA, Jewell EL, Alektiar KM, Hensley ML, et al. Low-volume lymph node metastasis discovered during sentinel lymph node mapping for endometrial carcinoma. Ann Surg Oncol. 2016;23(5):1653–9. https://doi.org/10.1245/s10434-015-5040-z.

    Article  PubMed  Google Scholar 

  34. How J, Gauthier C, Abitbol J, Lau S, Salvador S, Gotlieb R, et al. Impact of sentinel lymph node mapping on recurrence patterns in endometrial cancer. Gynecol Oncol. 2017;144(3):503–9. https://doi.org/10.1016/j.ygyno.2017.01.013.

    Article  PubMed  Google Scholar 

  35. Daraï E, Dubernard G, Bats AS, Heitz D, Mathevet P, Marret H, et al. Sentinel node biopsy for the management of early stage endometrial cancer: long-term results of the SENTI-ENDO study. Gynecol Oncol. 2015;136(1):54–9. https://doi.org/10.1016/j.ygyno.2014.09.011.

    Article  PubMed  Google Scholar 

  36. Plante M, Stanleigh J, Renaud MC, Sebastianelli A, Grondin K, Grégoire J. Isolated tumor cells identified by sentinel lymph node mapping in endometrial cancer: does adjuvant treatment matter? Gynecol Oncol. 2017;146(2):240–6. https://doi.org/10.1016/j.ygyno.2017.05.024.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gynecologic Center, International University of Health and Welfare Mita Hospital, Minato-ku, Tokyo, Japan

    Nobuyuki Susumu

  2. Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

    Nobuyuki Susumu, Wataru Yamagami, Fumio Kataoka, Takuro Hirano, Takeshi Makabe, Kensuke Sakai, Tatsuyuki Chiyoda, Hiroyuki Nomura, Akira Hirasawa & Daisuke Aoki

Authors
  1. Nobuyuki Susumu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wataru Yamagami
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fumio Kataoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takuro Hirano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takeshi Makabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kensuke Sakai
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tatsuyuki Chiyoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroyuki Nomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Akira Hirasawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Daisuke Aoki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nobuyuki Susumu .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Tokai University, Isehara, Japan

    Mikio Mikami

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Susumu, N. et al. (2019). Sentinel Node Navigation Surgery for Endometrial Cancer. In: Mikami, M. (eds) Surgery for Gynecologic Cancer. Comprehensive Gynecology and Obstetrics. Springer, Singapore. https://doi.org/10.1007/978-981-13-1519-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-1519-0_19

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-1518-3

  • Online ISBN: 978-981-13-1519-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation