Abstract
The regional lymph nodes in patients with endometrial cancer are usually categorized into pelvic lymph nodes and para-aortic lymph nodes. Thus, lymph node dissection in patients with endometrial cancer includes a wide variety of surgical procedures. Although the consensus is that pelvic lymphadenectomy is not necessary for patients with low-risk endometrial cancer, it is possible that combined pelvic and para-aortic lymphadenectomy is useful for patients with intermediate- and high-risk endometrial cancer. Another important aspect of lymphadenectomy is the risk of lymphedema of the lower extremities. Leg edema is the most frequent complication of lymphadenectomy. Therefore, lymphadenectomy must be tailored to maximize the therapeutic effect of surgery and minimize its invasiveness and adverse effects. Two strategies may be used: (1) removal of lymph nodes most likely to harbor disease with preservation of lymph nodes unlikely to be affected and (2) performance of full lymphadenectomy only in patients who can potentially benefit from this procedure with preservation of the lymph nodes most closely associated with the incidence of lymphedema.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kilgore LC, Partridge EE, Alvarez RD, Austin JM, Shingleton HM, Noojin F 3rd, Conner W. Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol. 1995;56:29–33.
Trimble EL, Kosary C, Park RC. Lymph node sampling and survival in endometrial cancer. Gynecol Oncol. 1998;71:340–3.
Fanning J. Long-term survival of intermediate risk endometrial cancer (stageIG3, IC, II) treated with full lymphadenectomy and brachytherapy without teletherapy. Gynecol Oncol. 2001;82:371–4.
Cragun JM, Havrilesky LJ, Calingaert B, Synan I, Secord AA, Soper JT, et al. Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer. J Clin Oncol. 2005;23:3668–75.
Lutman CV, Havrilesky LJ, Cragun JM, Secord AA, Calingaert B, Berchuck A, et al. Pelvic lymph node count is an important prognostic variable for FIGO stage I and II endometrial carcinoma with high-risk histology. Gynecol Oncol. 2006;102:92–7.
Chan JK, Wu H, Cheung MK, Shin JY, Osann K, Kapp DS. The outcome of 27,063 women with unstaged endometrioid uterine cancer. Gynecol Oncol. 2007;106:282–8.
Abu-Rustum NR, Iasonos A, Zhou Q, Oke E, Soslow RA, Alektiar KM, et al. Is there a therapeutic impact to regional lymphadenectomy in the surgical treatment of endometrial carcinoma? Am J Obstet Gynecol. 2008;198(457):E1–5.
Mariani A, Webb MJ, Galli L, Podratz KC. Potential therapeutic role of para-aortic lymphadenectomy in node-positive endometrial cancer. Gynecol Oncol. 2000;76:348–56.
Candiani GB, Belloni C, Maggi R, Colombo G, Frigoli A, Carinelli SG. Evaluation of different surgical approaches in the treatment of endometrial cancer at FIGO stage I. Gynecol Oncol. 1990;37:6–8.
Bar-Am A, Ron IG, Kuperminc M, Gal I, Jaffa A, Kovner F, Wigler N, et al. The role of routine pelvic lymph node sampling in patients with stage I endometrial carcinoma: second thoughts. Acta Obstet Gynecol Scand. 1998;77:347–50.
Sartori E, Gaddicci A, Landoni F, Lissoni A, Maggino T, Zola P, et al. Clinical behavior of 203 stage II endometrial cancer cases: the impact of primary surgical approach and of adjuvant radiation therapy. Int J Gynecol Cancer. 2001;11:430–7.
Hidaka T, Kato K, Yonezawa R, Shima T, Nakashima A, Nagira K, et al. Omission of lymphadenectomy is possible for low-risk corpus cancer. Eur J Surg Oncol. 2007;33:86–90.
Benedetti-Panici P, Basile S, Maneschi F, et al. Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst. 2008;100:1707–16.
ASTEC Study Group. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomized study. Lancet. 2009;373:125–36.
Todo Y, Kato H, Kaneuchi M, Watari H, Takeda M, Sakuragi N. Survival Effect of Para-aortic Lymphadenectomy in Endometrial Cancer (SEPAL Study): a retrospective cohort analysis. Lancet. 2010;375:1165–72.
Burke TW, Levenback C, Tornos C, Morris M, Wharton JT, Gershenson DM. Intraabdominal lymphatic mapping to direct selective pelvic and para-aortic lymphadenectomy in woman with high-risk endometrial cancer: results of a pilot study. Gynecol Oncol. 1996;62:169–73.
Niikura H, Okamura C, Utsunomiya H, Yoshinaga K, Akahira J, Ito K, Yaegashi N. Sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol. 2004;92:669–74.
Mariani A, Dowdy SC, Cliby WA, Gostout BS, Jones MB, Wilson TO, Podratz KC. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol. 2008;109:11–8.
Fotopoulou C, Savvatis K, Kraetschell R, Schefold JC, Lichtenegger W, Sehouli J. Systematic pelvic and aortic lymphadenectomy in intermediate and high-risk endometrial cancer: lymph-node mapping and identification of predictive factors for lymph-node status. Eur J Obstet Gynecol Reprod Biol. 2010;149:199–203.
Mariani A, Webb MJ, Keeney GL, Hoddock MG, Calori G, Podratz KC. Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol. 2000;182:1506–19.
Tuomi T, Pasanen A, Luomaranta A, Leminen A, Bützow R, Loukovaara M. Risk-stratification of endometrial carcinomas revisited: a combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease. Gynecol Oncol. 2015;137:23–7.
Tuomi T, Pasanen A, Leminen A, Bützow R, Loukovaara M. Prediction of lymphatic dissemination in endometrioid endometrial cancer: comparison of three risk-stratification models in a single-institution cohort. Gynecol Oncol. 2017;144:510–4.
Cox Bauer CM, Greer DM, Kram JJF, Kamelle SA. Tumor diameter as a predictor of lymphatic dissemination in endometrioid endometrial cancer. Gynecol Oncol. 2016;141:199–205.
Todo Y, Okamoto K, Hayashi M, Minobe S, Nomura E, Hareyama H, et al. A validation study of a scoring system to estimate the risk of lymph node metastasis for patients with endometrial carcinoma for tailoring the indication of lymphadenectomy. Gynecol Oncol. 2007;104:623–8.
Todo Y, Choi HJ, Kang S, Kim JWMD, Nam JH, Watari H, Tamakoshi A, Sakuragi N. Clinical significance of tumor volume in endometrial cancer: a Japan-Korea cooperative study. Gynecol Oncol. 2013;131:294–8.
Kang S, Kang WD, Chung HH, Jeong DH, Seo SS, Lee JM, et al. Preoperative identification of a low-risk group for lymph node metastasis in endometrial cancer: a Korean gynecologic oncology group study. J Clin Oncol. 2012;30:1329–34.
Kang S, Todo Y, Odagiri T, Mitamura T, Watari H, Kim JW, Nam JH, Sakuragi N. A low-risk group for lymph node metastasis is accurately identified by Korean gynecologic oncology group criteria in two Japanese cohorts with endometrial cancer. Gynecol Oncol. 2013;129:33–7.
Bendifallah S, Canlorbe G, Raimond E, Hudry D, Coutant C, Graesslin O, Touboul C, Huguet F, Cortez A, Daraï E, Ballester M. A clue towards improving the European Society of Medical Oncology risk group classification in apparent early stage endometrial cancer? Impact of lymphovascular space invasion. Br J Cancer. 2014;110:2640–6.
Vargas R, Rauh-Hain JA, Clemmer J, Clark RM, Goodman A, Growdon WB, Schorge JO, Del Carmen MG, Horowitz NS, Boruta DM 2nd. Tumor size, depth of invasion, and histologic grade as prognostic factors of lymph node involvement in endometrial cancer: a SEER analysis. Gynecol Oncol. 2014;133:216–20.
Milam MR, Java J, Walker JL, Metzinger DS, Parker LP, Coleman RL. Nodal metastasis risk in endometrioid endometrial cancer. Obstet Gynecol. 2012;119:286–92.
Lefringhouse JR, Elder JW, Baldwin LA, Miller RW, DeSimone CP, van Nagell JR Jr, Samoyoa LM, West DS, Dressler EV, Liu M, Ueland FR. Prospective validation of an intraoperative algorithm to guide surgical staging in early endometrial cancer. Gynecol Oncol. 2017;145:50–4.
Crosbie EJ, Roberts C, Qian W, et al. Body mass index does not influence post-treatment survival in early stage endometrial cancer: results from the MRC ASTEC trial. Eur J Cancer. 2012;48:853–64.
Arem H, Park Y, Pelser C, et al. Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients. J Natl Cancer Inst. 2013;105:342–9.
von Gruenigen VE, Tian C, Frasure H, et al. Treatment effects, disease recurrence, and survival in obese women with early endometrial carcinoma: a Gynecologic Oncology Group study. Cancer. 2006;107:2786–91.
Mauland KK, Trovik J, Wik E, et al. High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer. Br J Cancer. 2011;104:921–6.
Chia VM, Newcomb PA, Trentham-Dietz A, et al. Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis. Int J Gynecol Cancer. 2007;17:441–6.
Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–38.
Modesitt SC, Tian C, Kryscio R, et al. Gynecologic Oncology Group. Impact of body mass index on treatment outcomes in endometrial cancer patients receiving doxorubicin and cisplatin: a Gynecologic Oncology Group study. Gynecol Oncol. 2007;105:59–65.
Todo Y, Okamoto K, Minobe S, Kato H. Clinical significance of surgical staging for obese women with endometrial cancer: a retrospective analysis in a Japanese cohort. Jpn J Clin Oncol. 2014;44:903–9.
Kodama J, Seki N, Ojima Y, Nakamura K, Hongo A, Hiramatsu Y. Risk factors for early and late postoperative complications of patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol. 2006;124:222–6.
Konno Y, Todo Y, Minobe S, Kato H, Okamoto K, Sudu S, Takeda M, Watari H, Kaneuchi M, Sakuragi N. A retrospective analysis of postoperative complications with or without para-aortic lymphadenectomy in endometrial cancer. Int J Gynecol Cancer. 2011;21:385–90.
Abu-Rustum NR, Alekitar K, Iasonos A, Lev G, Sonoda Y, Aghajanian C, Chi DS, Barakat RR. The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: a 12-year experience at Memorial Sloan-Kettering Cancer Center. Gynecol Oncol. 2006;103:714–8.
Tada H, Teramukai S, Fukushima M, Sasaki H. Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma. BMC Cancer. 2009;9:47.
Todo Y, Yamamoto R, Minobe S, Suzuki Y, Takeshi U, Nakatani M, Aoyagi Y, Ohba Y, Okamoto K, Kato H. Risk factors for postoperative lower-extremity lymphedema in endometrial cancer survivors who had treatment including lymphadenectomy. Gynecol Oncol. 2010;119:60–4.
Tanaka T, Ohki N, Kojima A, Maeno Y, Miyahara Y, Sudo T, et al. Radiotherapy negates the effect of retroperitoneal nonclosure for prevention of lymphedema of the legs following pelvic lymphadenectomy for gynecological malignancies: an analysis from a questionnaire survey. Int J Gynecol Cancer. 2007;17:460–4.
Abu-Rustum NR, Barakat RR. Observations on the role of circumflex iliac node resection and the etiology of lower extremity lymphedema following pelvic lymphadenectomy for gynecologic malignancy. Gynecol Oncol. 2007;106:4–5.
Hareyama H, Ito K, Hada K, Uchida A, Hayakashi Y, Hirayama E, Oikawa M, Okuyama K. Reduction/prevention of lower extremity lymphedema after pelvic and para-aortic lymphadenectomy for patients with gynecologic malignancies. Ann Surg Oncol. 2012;19:268–73.
Matsumoto K, Yoshikawa H, Yasugi T, Onda T, Nakagawa S, Yamada M, Kawana K, Minaguchi T, Oda K, Hasumi Y, Taketani Y. Distinct lymphatic spread of endometrial carcinoma in comparison with cervical and ovarian carcinomas. Cancer Lett. 2002;180:83–9.
Todo Y, Kato H, Okamoto K, Minobe S, Suzuki Y, Ohba Y, Takeda M, Watari H, Kaneuchi M, Sakuragi N. Incidence of metastasis in circumflex iliac nodes distal to the external iliac nodes in intermediate- and high-risk endometrial cancer. Gynecol Oncol. 2011;122:55–8.
Weinberger V, Cibula D, Zikan M. Lymphocele: prevalence and management in gynecological malignancies. Expert Rev Anticancer Ther. 2014;14:307–17.
Zikan M, Fischerova D, Pinkavova I, Slama J, Weinberger V, Dusek L, Cibula D. A prospective study examining the incidence of asymptomatic and symptomatic lymphoceles following lymphadenectomy in patients with gynecological cancer. Gynecol Oncol. 2015;137:291–8.
Suzuki M, Ohwada M, Sato I. Pelvic lymphocysts following retroperitoneal lymphadenectomy: retroperitoneal partial "no-closure" for ovarian and endometrial cancers. J Surg Oncol. 1998;68:149–52.
Charoenkwan K, Kietpeerakool C. Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in patients with gynaecological malignancies. Cochrane Database Syst Rev. 2014;6:CD007387.
Fujita K, Nagano T, Suzuki A, Sakakibara A, Takahashi S, Hirano T, Okagaki A, Ban C. Incidence of postoperative ileus after para-aortic lymph node dissection in patients with malignant gynecologic tumors. Int J Clin Oncol. 2005;10:187–90.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Todo, Y. (2019). Retroperitoneal Lymph Node Dissection. In: Mikami, M. (eds) Surgery for Gynecologic Cancer. Comprehensive Gynecology and Obstetrics. Springer, Singapore. https://doi.org/10.1007/978-981-13-1519-0_17
Download citation
DOI: https://doi.org/10.1007/978-981-13-1519-0_17
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-1518-3
Online ISBN: 978-981-13-1519-0
eBook Packages: MedicineMedicine (R0)