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In Situ Measuring Mechanical Properties of Normal and Disease Cells

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Atomic Force Microscopy in Molecular and Cell Biology

Abstract

Atomic force microscopy (AFM) has recently made great progress in mapping local mechanical properties of a single cell including living cell. These mechanical properties can provide not only cellular nano- and micro-structure, but also physiological and pathological information of cells. Here, the recent applications of AFM for the study of mechanical characteristics of normal cells and disease cells are reviewed.

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Acknowledgement

This work was supported by Guangdong Natural Science Foundation, China (No. 2016A030313078), the Fundamental Research Funds for the Central Universities, China (No. 21617430), Foundation for Distinguished Young Talents in Higher Education of Guangdong, China (No. LYM11020), and Macau FDCT (No. 028/2014/A1).

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Authors and Affiliations

  1. Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, People’s Republic of China

    Sui-Ping Deng, Yi-Li Yang, Xing-Xing Cheng & Wen-Rong Li

  2. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China

    Jiye Cai

  3. Department of Chemistry, Jinan University, Jinan, China

    Jiye Cai

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  1. Sui-Ping Deng
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  2. Yi-Li Yang
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  3. Xing-Xing Cheng
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  4. Wen-Rong Li
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Correspondence to Sui-Ping Deng or Jiye Cai .

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  1. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China

    Jiye Cai

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Deng, SP., Yang, YL., Cheng, XX., Li, WR., Cai, J. (2018). In Situ Measuring Mechanical Properties of Normal and Disease Cells. In: Cai, J. (eds) Atomic Force Microscopy in Molecular and Cell Biology. Springer, Singapore. https://doi.org/10.1007/978-981-13-1510-7_9

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