Role of Alcohol and Metabolic Diseases in Colorectal Carcinogenesis

  • Tetsuji TakayamaEmail author
  • Yasushi Sato
  • Naoki Muguruma


Alcohol consumption was significantly associated with a risk of colorectal cancer with a relative risk ranging from 1.10 to 1.44 depending on the amount of intake. However, light intake of alcohol was not associated with incidence of colorectal cancer. Metabolic syndrome was also significantly associated with a risk of colorectal cancer with a relative risk ranging from 1.25 to 1.41. Of the four components of metabolic syndrome, dysglycemia and obesity were particularly associated with colorectal cancer risk. High levels of serum triglyceride were associated with increased colorectal cancer risk. However, there was no apparent association between raised blood pressure and colorectal cancer risk.


Alcohol Metabolic syndrome Colorectal cancer Relative risk Dysglycemia Obesity 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Tetsuji Takayama
    • 1
    Email author
  • Yasushi Sato
    • 2
  • Naoki Muguruma
    • 1
  1. 1.Department of Gastroenterology and OncologyInstitutes of Biomedical Sciences, Tokushima University Graduate SchoolTokushimaJapan
  2. 2.Department of Community Medicine for Gastroenterology and OncologyInstitutes of Biomedical Sciences, Tokushima University Graduate SchoolTokushimaJapan

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